• Thwarting cancer’s spread

    Nicole Davis, June 27th, 2016

    International team probes unique collection of early- and late-stage endometrial tumors to shed light on the biology of metastasis

    A tumor’s ability to spread to other parts of the body is among its deadliest capabilities. Unfortunately, it is also one of the most poorly understood. By unlocking the biology of this process, known as metastasis, scientists hope to open up new therapeutic avenues for a variety of cancers that, once metastasized, are largely incurable.

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  • Getting smart about antibiotics

    Nicole Davis, May 11th, 2016

    Broad institute member James Collins demystifies how antibiotics work, laying a path toward smarter, more effective use of existing bacteria-fighting drugs

    The widespread use of antibiotics marked a major turning point in medical history. Bacterial infections that once disfigured or killed their hosts could be neutralized simply, swiftly, and, for the most part, safely.

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  • In search of a telltale sign

    Nicole Davis, February 1st, 2016

    By scouring the genomes of a mysterious, blood vessel-hugging brain tumor in children, researchers unearth a single mutation that helps unlock its biology

    Cancer can be a devastating diagnosis at any age, but it is particularly tragic in young children. While many pediatric tumors are now readily treated or even cured, for other forms, particularly tumors of the brain, the outcomes are not so rosy.

    And yet, somewhat surprisingly, these childhood cancers remain understudied and underfunded relative to their adult counterparts.

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  • Seeking common ground in cancer cell line data

    Nicole Davis, November 19th, 2015

    The field of pharmacogenomics lies at the scalpel’s edge of personalized medicine, harnessing genomic tools to guide the use of drugs to treat disease. The idea is to marry precision with power — the right drug at the right time in the right patient. In cancer, researchers across the world have created two massive databases to help propel the biomedical community toward this goal.

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  • An auspicious day

    Nicole Davis, February 15th, 2011

    Ten years ago today, a groundbreaking paper was published in the journal Nature. It was a first full glimpse of our genetic blueprint, our DNA, made possible in part through the efforts of scientists at the Whitehead Institute Center for Genome Research (which later became part of the Broad).

    Today, we commemorate this historic achievement and the scientific knowledge it has made possible.

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  • Celebrating the fruits of the human genome sequence

    Nicole Davis, February 9th, 2011

    This week’s issue of the journal Nature celebrates a milestone in the history of biomedical research: the publication of the first draft of the human genome sequence. Ten years ago this week, two papers, one in Nature and one in Science, together offered the first glimpse of the genetic instructions written within our DNA.

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  • Chemical space: the final frontier

    Nicole Davis, December 22nd, 2010

    As the famous first words of Star Trek suggest, space is often considered the “final frontier” — a vast region beyond our tiny world that is largely unknown and yet to be explored. But for some Broad scientists, that distinction goes to a decidedly different area: chemical space.

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  • Time to retreat

    Nicole Davis, November 8th, 2010 | Filed under

    This week, the Broad community gathers for its annual scientific retreat, a two-day extravaganza featuring presentations and posters on a variety of research projects across the institute.

    Since all of us bloggers will be there, taking in the impressive line-up of science and scientists, and soaking up new information and ideas, BroadMinded will go dark on Monday and Tuesday.

    We’ll return, renewed and refreshed, on Wednesday.

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  • Broad earns “top” honor

    Nicole Davis, November 5th, 2010 | Filed under

    Some incredible news today in the Boston Globe: the Broad Institute is among the “Top Places to Work” in Massachusetts in 2010.

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  • A cast of 1000 genomes

    Nicole Davis, October 27th, 2010 | Filed under

    Nearly every week, new genomes are welcomed into the vast annals of modern science. Indeed, genomic research is moving at an ever-increasing pace, as the machines that decode — or “sequence” — DNA churn out data faster and more cheaply than ever before.

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