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  • The Broad's festive science images, part 2: Neuronal culture from stem cells

    Leah Eisenstadt, December 27th, 2010 | Filed under

    Here at the BroadMinded Blog, we polled the Broad community for their best holiday-themed scientific imagery — and we got some wonderful responses. We'll be taking a break until the new year, but in the meantime, enjoy these gorgeous biological images sure to keep you in the holiday spirit. Check back each day for a new entry. See you in 2011!

    The image on the right, contributed by Rakesh Karmacharya, features a neuronal culture derived from human induced pluripotent stem cells. Neurons are in green, glial cells are in red and the blue stain shows cell nuclei.

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  • The Broad's festive science images, part 1: Dendritic networks

    Leah Eisenstadt, December 24th, 2010 | Filed under

    Here at the BroadMinded Blog, we polled the Broad community for their best holiday-themed scientific imagery — and we got some wonderful responses. We'll be taking a break until the new year, but in the meantime, enjoy these gorgeous biological images sure to keep you in the holiday spirit. Check back each day for a new entry. See you in 2011!

    This pair of images below displays neuronal dendrites, which resemble wintry, cracked ice on a frozen pond.

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  • Broad analytical tool finds mutations in the driver's seat

    Leah Eisenstadt, December 17th, 2010 | Filed under

    Earlier this week, a team of scientists including Broad researcher Rameen Beroukhim, also a physician at Dana-Farber Cancer Institute, published exciting results from a study of squamous cell lung cancer, a disease linked to smoking. The scientists analyzed samples of lung tumors and discovered a mutation in the gene known as fibroblast growth factor receptor 1 (FGFR1) that was more common in samples of squamous cell lung cancer tumors than those of other types of lung cancer.

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  • Meet one of the Broad's laboratory workhorses

    Leah Eisenstadt, December 7th, 2010 | Filed under

    Behind an invisible curtain of light, robotic pods suspend drops of liquid in tiny plastic cones and deliver crucial chemicals to DNA destined for analysis. This automated dance takes place in the Biomek FX, a key piece of equipment in the Broad Institute's Genetic Analysis Platform (GAP) laboratory, where members of the Whole Genome Team prepare samples of genetic material for genotyping. The machine is an automatic pipettor, transferring liquids to samples during chemistry steps making work much easier for research technicians Mike DaSilva, Ryan McGinty, and Teni Minnetyan.

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  • What is an ORF?

    Leah Eisenstadt, November 30th, 2010 | Filed under

    Last week, researchers at the Broad announced exciting study results that reveal how cancer cells can evade treatment and become resistant. They found that although anti-melanoma drugs can block the B-RAF gene that drives these cancers, malignant melanoma cells can “turn on” another gene called COT and survive, pointing to this gene as another potential target for therapy.

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  • Carolina Wahlby helps roundworms take center stage

    Leah Eisenstadt, November 23rd, 2010 | Filed under

    Here on the blog last month we introduced you to the roundworm C. elegans, a scientific star among worms. At the Broad, a team of scientists led by computational biologist Carolina Wahlby is now helping C. elegans take center stage with new tools for high-throughput analysis of worm images.

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  • Dog research featured on TV's NOVA

    Leah Eisenstadt, November 18th, 2010 | Filed under

    A recent episode of PBS's NOVA series features the Broad Institute and researcher Elinor Karlsson. The program, Dogs Decoded, offers a scientific view of how dogs evolved from wolves, how their species is uniquely connected to ours, and what researchers are learning about human disease by studying dog genomes.

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  • Broadies take the seven words challenge

    Leah Eisenstadt, November 15th, 2010 | Filed under

    Our colleagues in New Zealand took the seven words challenge: Can you describe your scientific pursuits in seven words or less? We posed the question to our own scientists here at the Broad and got some enlightening results!

    Taking the guesswork out of cancer

    I discover the molecular causes of cancer

    Assemble genome sequence from billions of pieces

    DNA isolation, preparation, quantification, management and storage

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  • Beyond the Genome: Uncovering evolution’s driving forces in the human genome

    Leah Eisenstadt, November 3rd, 2010 | Filed under

    Last week, here on the blog we told you about some of the exciting results to come from the recently completed pilot phase of the 1000 Genomes Project. Scientists in the consortium sequenced several hundred genomes and captured even more of the variation among human genomes than had been previously known. The project aims to not only employ “next-generation” sequencing technologies at a scale never before achieved, it also aims to create the best map of human genetic variation so far.

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  • Beyond the Genome: New uses for DNA sequencers

    Leah Eisenstadt, November 2nd, 2010 | Filed under

    Once upon a time, sequencing the human genome took tens of millions of dollars and a warehouse full of DNA sequencing machines that analyzed samples throughout the day, and year after year. Now, less than a decade later, the same human genome sequence — the order of nucleotides or “letters” — can be generated using a single machine that analyzes samples for a few days, and for about 100-fold lower cost.

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