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  • Lots of variation uncovered, but more remains hidden

    Leah Eisenstadt, February 7th, 2011 | Filed under

    As data from the Human Genome Project accumulated, scientists realized that there was a significant amount of variation in the human genome, especially in the form of single-letter changes known as single nucleotide polymorphisms (SNPs). The study of SNPs in the human genome and their influence on disease has been a major focus of genome research over the past decade and has revealed hundreds of SNPs associated with common diseases.

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  • Mentoring is in full swing at the Broad

    Leah Eisenstadt, January 27th, 2011 | Filed under

    January is National Mentoring Month, so it’s a nice time to reflect on our mentoring experiences. Many in the Broad community have at one time served as a mentor, a mentee, or both. Mentors at the Broad can be found at all levels, from research technicians up to core faculty members. The mentoring relationship is an essential one on the path to becoming a scientist, as many who enter the field are first inspired by a scientist or teacher they view as a role model.

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  • The Broad's festive science images, part 5: Liver cells, in color

    Leah Eisenstadt, January 5th, 2011 | Filed under

    Here at the BroadMinded Blog, we polled the Broad community for their best holiday-themed scientific imagery — and we got some wonderful responses. We posted a few at the end of 2010, and here's one more!

    This stunning picture is a false-colored microscopic image of human liver cells grown with mouse fibroblasts in vitro. The cellular model is useful for identifying changes in liver cells when treated with drugs. In this image, a blue stain marks the liver cell DNA, and green stains the cells' endoplasmic reticulum.

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  • Was that a typo?

    Leah Eisenstadt, January 4th, 2011 | Filed under

    Last month, we announced results from an international study of DNA from an exceptionally well-preserved finger bone found in Denisova Cave in southern Siberia. The work, led by scientists at Max Planck Institute for Evolutionary Anthropology with contributions from several Broad researchers, provides evidence that a previously unknown class of human — dubbed the Denisovans — walked the earth at least 30,000 years ago alongside modern humans, Neandertals, and the “hobbit” of Flores.

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  • The Broad's festive science images, part 4: Triangular cells

    Leah Eisenstadt, December 29th, 2010 | Filed under

    Here at the BroadMinded Blog, we polled the Broad community for their best holiday-themed scientific imagery — and we got some wonderful responses. We'll be taking a break until the new year, but in the meantime, enjoy these gorgeous biological images sure to keep you in the holiday spirit. Check back each day for a new entry. See you in 2011!

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  • The Broad's festive science images, part 3: Chemical screening data

    Leah Eisenstadt, December 28th, 2010 | Filed under

    Here at the BroadMinded Blog, we polled the Broad community for their best holiday-themed scientific imagery — and we got some wonderful responses. We'll be taking a break until the new year, but in the meantime, enjoy these gorgeous biological images sure to keep you in the holiday spirit. Check back each day for a new entry. See you in 2011!

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  • The Broad's festive science images, part 2: Neuronal culture from stem cells

    Leah Eisenstadt, December 27th, 2010 | Filed under

    Here at the BroadMinded Blog, we polled the Broad community for their best holiday-themed scientific imagery — and we got some wonderful responses. We'll be taking a break until the new year, but in the meantime, enjoy these gorgeous biological images sure to keep you in the holiday spirit. Check back each day for a new entry. See you in 2011!

    The image on the right, contributed by Rakesh Karmacharya, features a neuronal culture derived from human induced pluripotent stem cells. Neurons are in green, glial cells are in red and the blue stain shows cell nuclei.

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  • The Broad's festive science images, part 1: Dendritic networks

    Leah Eisenstadt, December 24th, 2010 | Filed under

    Here at the BroadMinded Blog, we polled the Broad community for their best holiday-themed scientific imagery — and we got some wonderful responses. We'll be taking a break until the new year, but in the meantime, enjoy these gorgeous biological images sure to keep you in the holiday spirit. Check back each day for a new entry. See you in 2011!

    This pair of images below displays neuronal dendrites, which resemble wintry, cracked ice on a frozen pond.

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  • Broad analytical tool finds mutations in the driver's seat

    Leah Eisenstadt, December 17th, 2010 | Filed under

    Earlier this week, a team of scientists including Broad researcher Rameen Beroukhim, also a physician at Dana-Farber Cancer Institute, published exciting results from a study of squamous cell lung cancer, a disease linked to smoking. The scientists analyzed samples of lung tumors and discovered a mutation in the gene known as fibroblast growth factor receptor 1 (FGFR1) that was more common in samples of squamous cell lung cancer tumors than those of other types of lung cancer.

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  • Meet one of the Broad's laboratory workhorses

    Leah Eisenstadt, December 7th, 2010 | Filed under

    Behind an invisible curtain of light, robotic pods suspend drops of liquid in tiny plastic cones and deliver crucial chemicals to DNA destined for analysis. This automated dance takes place in the Biomek FX, a key piece of equipment in the Broad Institute's Genetic Analysis Platform (GAP) laboratory, where members of the Whole Genome Team prepare samples of genetic material for genotyping. The machine is an automatic pipettor, transferring liquids to samples during chemistry steps making work much easier for research technicians Mike DaSilva, Ryan McGinty, and Teni Minnetyan.

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