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After completing graduate school, computational scientist Miriah Meyer noticed a disappointing trend in data visualization. “Our field is usually about generalities,” she says. “We create algorithms or systems that are very general for some broad class of problems or types of data.” But Miriah saw that these solutions, especially those for the analysis of biological data, often didn’t help answer the specific questions of scientists using them.
Yesterday on the blog, we introduced you to some of the Broad researchers who built tools, teams, and resources to generate and analyze a massive flood of data and analytical code for The Cancer Genome Atlas (TCGA). Today we give you a look at the system they built to manage data analysis for the project: Firehose.
In this two-part series, we’ll give you a look at some of the tools, teams, and resources built by Broad Institute scientists to support the large-scale cancer sequencing project known as The Cancer Genome Atlas (TCGA).
Cells use a complex network of connections to make a constant array of decisions about their surrounding environment: Is it time to grow? Is it time to change into a different type of cell? When a cellular component or connection is missing or defective, disease takes hold.
This spring, artists, designers, computational biologists, and software engineers gathered in the Broad Institute auditorium for three days of talks, posters, and tutorials on the cutting-edge field of visualization in biology.
Back in May, we told you on the blog about Trinity, a suite of tools that assembles transcripts, or bits of RNA that have been copied from a cell’s genome, into a “transcriptome,” even without a reference genome handy.
Last week on the Broad website, we told you about a new approach to detect and verify biomarkers, using the search for signals of heart attack as a test case. In this study, the team of scientists from the Broad Institute and Massachusetts General Hospital looked for proteins in the blood that are released when heart cells are injured and that can be detected quickly after the attack.
After a storied career running a multimillion-dollar business, Ted Stanley and his wife, Vada, set up a philanthropic foundation in the 1980s to invest in good causes. Their goals became a lot more focused when their son developed bipolar disorder and needed treatment. The Stanleys considered themselves fortunate that the drug lithium successfully treated his symptoms – and they want to make sure that someday, there is a much wider range of options for others with psychiatric illness.
Six years ago, a team of researchers at the Broad faced a challenge: researchers the world over were using microarrays – chips covered with microscopic fragments of DNA – to measure the expression, or activity, of genes, but the tools to analyze the data from these large-scale studies were often out of the direct reach of biomedical researchers.