• Visualizing a genome in disarray

    Leah Eisenstadt, May 16th, 2012

    Last week on the Broad website, we featured recent work by Broad researchers that can shed new light on the massive genomic changes taking place in cancer cells. The genomes in tumors are often drastically disorganized, with large chunks of missing or extra DNA — even whole chromosomes — in addition to smaller, single-letter mutations. These alterations can complicate the search for genetic changes underlying cancer.

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  • A close-up look at a tiny, yet powerful, chip

    Leah Eisenstadt, January 4th, 2012 | Filed under

    This past October, we announced that Paul Blainey, an expert in single-molecule and single-cell approaches, would be joining the Broad as a core faculty member in early 2012. He will join us after completing postdoctoral research at Stanford University in the laboratory of Stephen Quake, where he has pioneered novel methods to perform single-cell microbial sequencing. As part of this work, he designed a 3.5-cm microfluidic chip that sorts single cells and amplifies their genomes to prepare for sequencing.

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  • Revisiting our festive science images

    Leah Eisenstadt, December 27th, 2011 | Filed under

    Last year during the holiday season, we invited Broad researchers to submit scientific images with a seasonal flair. We thought it would be fun to revisit those images, resembling holiday lights, cracked ice, and tinsel. Enjoy this slideshow of festive imagery from the world of science as we count down to the new year!

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  • Behind the Scenes: Building the Broad’s cloud

    Leah Eisenstadt, December 8th, 2011 | Filed under

    Broadies are pros at sharing. They share ideas, data, equipment, and even bikes. So it may be no surprise to learn that behind the scenes of the Broad’s fast-paced research computing network for data collection and analysis, servers have been quietly getting in the sharing game, too, going “virtual” to save the Broad money, energy, and space and to keep pace with the growing demand for efficient computing by large and diverse research projects throughout the institute.

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  • A fresh approach to data visualization

    Leah Eisenstadt, September 21st, 2011 | Filed under

    After completing graduate school, computational scientist Miriah Meyer noticed a disappointing trend in data visualization. “Our field is usually about generalities,” she says. “We create algorithms or systems that are very general for some broad class of problems or types of data.” But Miriah saw that these solutions, especially those for the analysis of biological data, often didn’t help answer the specific questions of scientists using them.

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  • Venturing into noncoding RNA

    Leah Eisenstadt, August 29th, 2011

    The central dogma of molecular biology states that DNA makes RNA, which makes protein, the functional players in the cell. But like most rules, this one has some exceptions.

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  • Behind the scenes of The Cancer Genome Atlas: part 2

    Leah Eisenstadt, August 11th, 2011 | Filed under

    Yesterday on the blog, we introduced you to some of the Broad researchers who built tools, teams, and resources to generate and analyze a massive flood of data and analytical code for The Cancer Genome Atlas (TCGA). Today we give you a look at the system they built to manage data analysis for the project: Firehose.

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  • Behind the scenes of The Cancer Genome Atlas: part 1

    Leah Eisenstadt, August 10th, 2011 | Filed under

    In this two-part series, we’ll give you a look at some of the tools, teams, and resources built by Broad Institute scientists to support the large-scale cancer sequencing project known as The Cancer Genome Atlas (TCGA).

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  • Highlights from the 2010 Annual Report: Aviv Regev focuses on how cells are “wired”

    Leah Eisenstadt, August 3rd, 2011 | Filed under

    Cells use a complex network of connections to make a constant array of decisions about their surrounding environment: Is it time to grow? Is it time to change into a different type of cell? When a cellular component or connection is missing or defective, disease takes hold.

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  • Biology visualization workshop videos now online

    Leah Eisenstadt, July 29th, 2011 | Filed under

    This spring, artists, designers, computational biologists, and software engineers gathered in the Broad Institute auditorium for three days of talks, posters, and tutorials on the cutting-edge field of visualization in biology.

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