• What is an ORF?

    Leah Eisenstadt, November 30th, 2010 | Filed under

    Last week, researchers at the Broad announced exciting study results that reveal how cancer cells can evade treatment and become resistant. They found that although anti-melanoma drugs can block the B-RAF gene that drives these cancers, malignant melanoma cells can “turn on” another gene called COT and survive, pointing to this gene as another potential target for therapy.

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  • Can you patent a nose? A gene?

    Ellen Clegg, November 29th, 2010 | Filed under

    Can you patent a nose?

    That was one of a myriad of provocative questions at a recent panel called “Gene Patenting: Balancing Access and Innovation” co-sponsored by the Broad and the American Civil Liberties Union of Massachusetts. (That’s myriad with a lower-case ‘m’ – not to be confused with the controversy that recently burst into the news in a court case known as ACLU v. Myriad Genetics. The more formal name is The Association for Molecular Pathology, et al. v. The United States Patent and Trademark Office, et al.)

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  • Carolina Wahlby helps roundworms take center stage

    Leah Eisenstadt, November 23rd, 2010 | Filed under

    Here on the blog last month we introduced you to the roundworm C. elegans, a scientific star among worms. At the Broad, a team of scientists led by computational biologist Carolina Wahlby is now helping C. elegans take center stage with new tools for high-throughput analysis of worm images.

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  • Dog research featured on TV's NOVA

    Leah Eisenstadt, November 18th, 2010 | Filed under

    A recent episode of PBS's NOVA series features the Broad Institute and researcher Elinor Karlsson. The program, Dogs Decoded, offers a scientific view of how dogs evolved from wolves, how their species is uniquely connected to ours, and what researchers are learning about human disease by studying dog genomes.

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  • Come celebrate Darwin at the Broad Institute!

    Haley Bridger, November 17th, 2010 | Filed under

    This Friday, November 19, at 7:30 pm, come to the Broad Institute auditorium at 7 Cambridge Center for “Darwin and the Debate over Human Origins,” a free and public symposium organized by the Darwin Bicentennial Project and Science of the Eye. The event marks the 151st anniversary of Darwin’s On the Origin of Species and will feature talks by Darwin scholar and author Janet Browne, Broad associate member David Reich, and other distinguished speakers from Harvard and MIT.

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  • Five Questions for Nir Hacohen

    Haley Bridger, November 16th, 2010 | Filed under

    Your immune system is quite clever. It can sense when bacteria, viruses, or pathogens are invading, distinguish among them, and respond accordingly. But an overactive or improperly functioning immune system can lead to a variety of problems such as auto-immune diseases like lupus or diseases related to inflammation, such as hardening of the arteries (atherosclerosis). Nir Hacohen and his colleagues at the Broad Institute and Massachusetts General Hospital want to find out more about the intricacies of how the immune system works and how it relates to these diseases.

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  • Broadies take the seven words challenge

    Leah Eisenstadt, November 15th, 2010 | Filed under

    Our colleagues in New Zealand took the seven words challenge: Can you describe your scientific pursuits in seven words or less? We posed the question to our own scientists here at the Broad and got some enlightening results!

    Taking the guesswork out of cancer

    I discover the molecular causes of cancer

    Assemble genome sequence from billions of pieces

    DNA isolation, preparation, quantification, management and storage

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  • Numbers game

    Ellen Clegg, November 13th, 2010 | Filed under

    A common thread stitches together Nick Patterson’s numerous careers: deep and joyful thinking about mathematics. He has cracked Cold War codes and run numbers on Wall Street. Now a computational biologist in the Broad’s Program in Medical and Population Genetics, he has helped colleagues analyze the migration and mixing of human populations. His work has spanned epochs and analyzed the population history of an entire subcontinent.

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  • Veterans Day

    Alice McCarthy, November 11th, 2010


    Image courtesy of the US Department of Veterans Affairs

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  • Time to retreat

    Nicole Davis, November 8th, 2010 | Filed under

    This week, the Broad community gathers for its annual scientific retreat, a two-day extravaganza featuring presentations and posters on a variety of research projects across the institute.

    Since all of us bloggers will be there, taking in the impressive line-up of science and scientists, and soaking up new information and ideas, BroadMinded will go dark on Monday and Tuesday.

    We’ll return, renewed and refreshed, on Wednesday.

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