• Opinionome: What will be the next big –ome?

    Tom Ulrich, June 16th, 2016

    The variety of –omes and –omic sciences has exploded in the last 20 years. Proteomics, metagenomics, transcriptomics...which –omes are on the rise?

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  • A massive approach to finding what's "real" in genome-wide association data

    Tom Ulrich, June 2nd, 2016

    What could we learn if we probed the subtle effects of thousands of DNA variations on gene expression, all at once? Two recent Cell papers hint at how an assay called MPRA could help us get there.

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  • Getting smart about antibiotics

    Nicole Davis, May 11th, 2016

    Broad institute member James Collins demystifies how antibiotics work, laying a path toward smarter, more effective use of existing bacteria-fighting drugs

    The widespread use of antibiotics marked a major turning point in medical history. Bacterial infections that once disfigured or killed their hosts could be neutralized simply, swiftly, and, for the most part, safely.

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  • Deciphering chromatin: Many marks, millions of histones at a time

    Tom Ulrich, May 6th, 2016

    A new high-resolution technique for reading combinations of chemical flags in the epigenome could help uncover new rules underlying cell fate and provide important clues for understanding diseases like cancer.

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  • Time to light the FireCloud

    Tom Ulrich, May 3rd, 2016

    The Broad Cancer Genome Analysis group and Data Science Platform's suite of TCGA data and cancer genome analysis tools is open for evaluation.

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  • Smile for the camera, Cpf1

    Tom Ulrich, April 21st, 2016

    The crystal structure of CPF1 provides some intriguing insights into this CRISPR gene-editing enzyme.

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  • Cancer close-up: Single-cell approach provides detailed look inside tumors

    Members of the Klarman Cell Observatory at the Broad Institute and the Joint Center for Cancer Precision Medicine (CCPM) at the Dana-Farber Cancer Institute, Brigham and Women’s Hospital, and the Broad have embarked on an ambitious effort to use single-cell genome analysis to explore

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  • Roads Less Traveled

    Angela Page, April 13th, 2016

    Zuzana Tothova has a weakness for uncharted territory. It has inspired her to pursue an ambitious project at the Broad Institute of MIT and Harvard where she’s using a slew of novel technologies to better understand a blood disorders called myelodysplastic syndrome (MDS). But this weakness for the unknown runs deep and can even be blamed for how she found herself in the United States in the first place.

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  • Putting a face on rare disease

    Tom Ulrich, April 8th, 2016

    A traveling art exhibit featuring portraits of children with rare diseases comes to the Broad this spring to humanize and inspire research on these conditions.

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  • From spectrum to continuum

    Veronica Meade-Kelly, March 17th, 2016

    New research uses genetic and behavioral data to shed light on autism-associated traits in the general population

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