• He said, she said, the data said: Coming to consensus on genetic testing

    Tom Ulrich, July 26th, 2016

    As genetic tests become more widely available and widely adopted, clinical genetics is facing a crisis of consensus. But it doesn’t have to be this way.

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  • A model approach to tackling rare cancers

    Tom Ulrich, July 6th, 2016

    Researchers lack the cell line models they need to really dig into the biology of rare cancers. New efforts in in vitro modeling could change that.

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  • Reading vivax malaria’s global story in its genes

    Tom Ulrich, June 28th, 2016

    Plasmodium vivax is the chief malaria-causing parasite outside Africa, but we know relatively little about it. A study provides new insights into this neglected pathogen’s relationship with us.

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  • Thwarting cancer’s spread

    Nicole Davis, June 27th, 2016

    International team probes unique collection of early- and late-stage endometrial tumors to shed light on the biology of metastasis

    A tumor’s ability to spread to other parts of the body is among its deadliest capabilities. Unfortunately, it is also one of the most poorly understood. By unlocking the biology of this process, known as metastasis, scientists hope to open up new therapeutic avenues for a variety of cancers that, once metastasized, are largely incurable.

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  • Opinionome: What will be the next big –ome?

    Tom Ulrich, June 16th, 2016

    The variety of –omes and –omic sciences has exploded in the last 20 years. Proteomics, metagenomics, transcriptomics...which –omes are on the rise?

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  • A massive approach to finding what's "real" in genome-wide association data

    Tom Ulrich, June 2nd, 2016

    What could we learn if we probed the subtle effects of thousands of DNA variations on gene expression, all at once? Two recent Cell papers hint at how an assay called MPRA could help us get there.

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  • Getting smart about antibiotics

    Nicole Davis, May 11th, 2016

    Broad institute member James Collins demystifies how antibiotics work, laying a path toward smarter, more effective use of existing bacteria-fighting drugs

    The widespread use of antibiotics marked a major turning point in medical history. Bacterial infections that once disfigured or killed their hosts could be neutralized simply, swiftly, and, for the most part, safely.

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  • Deciphering chromatin: Many marks, millions of histones at a time

    Tom Ulrich, May 6th, 2016

    A new high-resolution technique for reading combinations of chemical flags in the epigenome could help uncover new rules underlying cell fate and provide important clues for understanding diseases like cancer.

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  • Time to light the FireCloud

    Tom Ulrich, May 3rd, 2016

    The Broad Cancer Genome Analysis group and Data Science Platform's suite of TCGA data and cancer genome analysis tools is open for evaluation.

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  • Smile for the camera, Cpf1

    Tom Ulrich, April 21st, 2016

    The crystal structure of CPF1 provides some intriguing insights into this CRISPR gene-editing enzyme.

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