Blog

  • Cancer gene found hiding in plain sight

    Veronica Meade-Kelly, October 27th, 2014

    A mutation that may be driving as many as 20 percent of endometrial and colorectal cancers has come to light this week, thanks to a study by researchers from the Broad Institute of MIT and Harvard and Dana-Farber Cancer Institute.

    The researchers describe finding the connection between the gene RNF43 and these cancers earlier this week in Nature Genetics.

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  • Broad Paper Vids: Metabolic changes signal early development of pancreatic cancer

    Paul Goldsmith, October 3rd, 2014

    Pancreatic cancer is the tenth most common cancer in the United States, but the fourth most common cause of cancer death. This disparity is due, in part, to the disease’s elusive nature. Because the pancreas is located deep in the abdomen, symptoms often present only after cancer has spread to other places in the body. But this week, a team of researchers from the Broad, Dana-Farber Cancer Institute, MIT, and elsewhere reported the discovery of metabolic changes that indicate early development of the disease.

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  • Broad Institute, Ragon Institute aim to help “end HIV” by awarding new catalytic grants

    Leah Eisenstadt, September 25th, 2014

    Despite significant gains made by the scientific and medical communities to understand the HIV virus, an effective HIV/AIDS vaccine – the best hope for ending the epidemic – is still out of reach.

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  • Sangeeta Bhatia awarded Lemelson-MIT Prize

    Veronica Meade-Kelly, September 8th, 2014

    Broad senior associate member Sangeeta Bhatia has been named the 2014 recipient of the $500,000 Lemelson-MIT Prize. The honor, which is celebrating its 20th year, recognizes outstanding, mid-career inventors who are improving the world through technological invention, and demonstrating a commitment to mentorship in science, technology, engineering, and mathematics.

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  • The Rabbit Rift

    Paul Goldsmith, September 4th, 2014

    By all accounts, Pope Gregory I was quite the innovator. Along with his many liturgical accomplishments, he’s credited (somewhat apocryphally) with popularizing Gregorian chant, coining the phrase ‘bless you’ after someone sneezes, and perhaps, most unwittingly, creating one of the best experimental models for studying the evolution of domesticated animals. 

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  • Ebola update: New research sheds light on origin, transmission of Sierra Leone outbreak

    Haley Bridger, September 2nd, 2014 | Filed under

    Researchers from the Broad Institute have been working with a team of international collaborators to collect samples, rapidly sequence genomes, and share data in order to accelerate response efforts to the ongoing outbreak of Ebola in West Africa. The team’s efforts culminate with a paper published online in the journal Science, but the story of their research and collaboration stretches back many years.

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  • Finding the mutations that matter

    Veronica Meade-Kelly, August 7th, 2014

    A major endeavor in genomics research, at the Broad Institute and beyond, is to identify the variations in the human genetic code that may be associated with disease. Such variations can point to potential drug targets or shed light on the biological mechanisms underlying a disease.

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  • Broad in the news: Ted Stanley’s extraordinary commitment to psychiatric research

    Paul Goldsmith, July 25th, 2014

    On Tuesday, July 22, the Broad Institute announced an unprecedented commitment of $650 million from philanthropist Ted Stanley to support psychiatric research. Stanley’s gift – the largest ever in psychiatric research and among the largest for scientific research in general – generated a great deal of coverage in the media.

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  • Broad Paper Vids: Peering into the transcriptome of single cells

    Leah Eisenstadt, July 2nd, 2014

    The ability to monitor the function and activity of single cells in isolation using RNA sequencing enables researchers to uncover the remarkable heterogeneity of tissues. Using a new microfluidic system to prepare cells for single-cell RNA sequencing, a team of scientists at the Broad Institute and Fluidigm, led by Broad core member Aviv Regev, associate member Hongkun Park, and Fluidigm scientist Andrew May, analyzed the transcriptomes of more than 1,700 primary mouse bone-marrow-derived dendritic cells.

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  • Broad in the news: New York Times covers landmark heart disease study by Broad researchers and colleagues

    Haley Bridger, June 27th, 2014 | Filed under

    By scouring the DNA of thousands of patients, researchers at the Broad Institute and Massachusetts General Hospital and their colleagues have discovered four rare mutations in the gene APOC3 that lower triglycerides and reduce a person’s risk of coronary heart disease — dropping it by 40 percent.

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