Getting smart about antibiotics

Nicole Davis, May 11th, 2016

Broad institute member James Collins demystifies how antibiotics work, laying a path toward smarter, more effective use of existing bacteria-fighting drugs

The widespread use of antibiotics marked a major turning point in medical history. Bacterial infections that once disfigured or killed their hosts could be neutralized simply, swiftly, and, for the most part, safely.

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Deciphering chromatin: Many marks, millions of histones at a time

Tom Ulrich, May 6th, 2016

A new high-resolution technique for reading combinations of chemical flags in the epigenome could help uncover new rules underlying cell fate and provide important clues for understanding diseases like cancer.

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Time to light the FireCloud

Tom Ulrich, May 3rd, 2016

The Broad Cancer Genome Analysis group and Data Science Platform's suite of TCGA data and cancer genome analysis tools is open for evaluation.

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Smile for the camera, Cpf1

Tom Ulrich, April 21st, 2016

The crystal structure of CPF1 provides some intriguing insights into this CRISPR gene-editing enzyme.

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Cancer close-up: Single-cell approach provides detailed look inside tumors

Members of the Klarman Cell Observatory at the Broad Institute and the Joint Center for Cancer Precision Medicine (CCPM) at the Dana-Farber Cancer Institute, Brigham and Women’s Hospital, and the Broad have embarked on an ambitious effort to use single-cell genome analysis to explore

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Roads Less Traveled

Angela Page, April 13th, 2016

Zuzana Tothova has a weakness for uncharted territory. It has inspired her to pursue an ambitious project at the Broad Institute of MIT and Harvard where she’s using a slew of novel technologies to better understand a blood disorders called myelodysplastic syndrome (MDS). But this weakness for the unknown runs deep and can even be blamed for how she found herself in the United States in the first place.

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Putting a face on rare disease

Tom Ulrich, April 8th, 2016

A traveling art exhibit featuring portraits of children with rare diseases comes to the Broad this spring to humanize and inspire research on these conditions.

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From spectrum to continuum

Veronica Meade-Kelly, March 17th, 2016

New research uses genetic and behavioral data to shed light on autism-associated traits in the general population

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Broad Institute joins White House Precision Medicine Summit with researchers, initiatives to drive health research forward

Paul Goldsmith, February 25th, 2016

On Thursday, February 25th, President Obama hosted a panel discussion as part of the White House Precision Medicine Initiative Summit, which included discussions of three Broad initiatives and research projects. The summit highlighted progress made as part of the President’s Precision Medicine Initiative (PMI).

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Good apart, better together

Lisa Girard, February 11th, 2016

Synergy between two large cancer datasets may help identify a targetable weakness across many cancers

When making a simple telescope, relative adjustments between two lenses can bring previously blurry objects sharply into focus. Peering through two such “lenses” recently led to a discovery that may help identify which patients could most benefit from taking aim at a potentially widespread cancer therapeutic target.

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