Reading vivax malaria’s global story in its genes

Tom Ulrich, June 28th, 2016

Plasmodium vivax is the chief malaria-causing parasite outside Africa, but we know relatively little about it. A study provides new insights into this neglected pathogen’s relationship with us.

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Thwarting cancer’s spread

Nicole Davis, June 27th, 2016

International team probes unique collection of early- and late-stage endometrial tumors to shed light on the biology of metastasis

A tumor’s ability to spread to other parts of the body is among its deadliest capabilities. Unfortunately, it is also one of the most poorly understood. By unlocking the biology of this process, known as metastasis, scientists hope to open up new therapeutic avenues for a variety of cancers that, once metastasized, are largely incurable.

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Opinionome: What will be the next big –ome?

Tom Ulrich, June 16th, 2016

The variety of –omes and –omic sciences has exploded in the last 20 years. Proteomics, metagenomics, transcriptomics...which –omes are on the rise?

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A massive approach to finding what's "real" in genome-wide association data

Tom Ulrich, June 2nd, 2016

What could we learn if we probed the subtle effects of thousands of DNA variations on gene expression, all at once? Two recent Cell papers hint at how an assay called MPRA could help us get there.

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Getting smart about antibiotics

Nicole Davis, May 11th, 2016

Broad institute member James Collins demystifies how antibiotics work, laying a path toward smarter, more effective use of existing bacteria-fighting drugs

The widespread use of antibiotics marked a major turning point in medical history. Bacterial infections that once disfigured or killed their hosts could be neutralized simply, swiftly, and, for the most part, safely.

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Deciphering chromatin: Many marks, millions of histones at a time

Tom Ulrich, May 6th, 2016

A new high-resolution technique for reading combinations of chemical flags in the epigenome could help uncover new rules underlying cell fate and provide important clues for understanding diseases like cancer.

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Time to light the FireCloud

Tom Ulrich, May 3rd, 2016

The Broad Cancer Genome Analysis group and Data Science Platform's suite of TCGA data and cancer genome analysis tools is open for evaluation.

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Smile for the camera, Cpf1

Tom Ulrich, April 21st, 2016

The crystal structure of CPF1 provides some intriguing insights into this CRISPR gene-editing enzyme.

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Cancer close-up: Single-cell approach provides detailed look inside tumors

Members of the Klarman Cell Observatory at the Broad Institute and the Joint Center for Cancer Precision Medicine (CCPM) at the Dana-Farber Cancer Institute, Brigham and Women’s Hospital, and the Broad have embarked on an ambitious effort to use single-cell genome analysis to explore

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Roads Less Traveled

Angela Page, April 13th, 2016

Zuzana Tothova has a weakness for uncharted territory. It has inspired her to pursue an ambitious project at the Broad Institute of MIT and Harvard where she’s using a slew of novel technologies to better understand a blood disorders called myelodysplastic syndrome (MDS). But this weakness for the unknown runs deep and can even be blamed for how she found herself in the United States in the first place.

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