Yujin Hoshida is a research scientist in the Cancer Program at the Broad Institute. His focus is on genomic profiling of clinical specimens obtained from patients with various types of cancer (mainly liver cancer) to identify and validate disease pathogenesis-related molecular information. Specifically, he identifies gene expression signatures predicting clinical outcomes in patients with cancer as well as various clinical phenotypes connected to malignant characteristics like tumor invasion or tumor metastasis. The goal of his work is to translate these findings to develop new diagnostics or enable development of new cancer therapies.
Hoshida earned his M.D degree from the University of Tsukuba and his Ph.D from the University of Tokyo in the area of hepatitis C virus molecular analysis. He has extensive clinical experience in internal medicine, gastroenterology, and hepatology. Before coming to the Broad in 2004, Hoshida spent years in clinic performing thousands of endoscopy, laparoscopy, radiographic diagnostic procedures, and angiographic/non-surgical treatments for cancer. He also focused on biostatistical research to define diagnostic and prognostic indices for gastrointestinal and liver diseases.
In 2009, Hoshida was the co-awardee of the Landon Foundation’s AACR INNOVATOR Award for International Collaboration in Cancer Research. He is currently serving as a member of the editorial board for several medical journals such as Clinical Cancer Research, Journal of Hepatology, PLoS ONE, and the review committee for the International Liver Cancer Association.Select Publications
Hoshida Y et al. Gene expression in fixed tissues and outcome in hepatocellular carcinoma. N Engl J Med. 2008 Nov 6;359(19):1995-2004. Epub 2008 Oct 15.
Villanueva A, et al. Combining clinical, pathology, and gene expression data to predict recurrence of hepatocellular carcinoma. Gastroenterology. 2011 May; 140(5): 1501-12
Hoshida Y, Toffanin et al. Molecular classification and novel targets in hepatocellular carcinoma: recent advancements. Semin Liver Dis. 2010 Feb; 30(1): 35-51.