Xiao Yang is a computational biologist in the viral group of the Genome Sequencing and Analysis Program at the Broad Institute. His main role is to develop algorithms and implement them in computer programs to analyze massive amounts of data from the institute’s “next-generation” sequencing machines.
Sequencing machines produce short segments of DNA sequence, known as reads. To know the full sequence of an organism’s genome, those reads must be pieced together in the correct order, a process known as assembly. Yang developed a program to assemble genomes of highly diverse populations of viruses without prior knowledge of the genomes’ structure. His next project will focus on detecting diversity and recovering haplotypes – chunks of DNA in common among organisms – among populations of viruses and microbes.
Yang joined the Broad in June 2011 after completing a Ph.D. in bioinformatics and computational biology at Iowa State University.Last updated date: April 2012