Suzanne Jacobs is the associate scientific director for the Diabetes Research Group, and a member of the Medical and Population Genetics and Metabolism Programs at the Broad Institute of MIT and Harvard. In these roles, Jacobs helps lead a multidisciplinary research program that aims to determine genetic contributors to type 2 diabetes and to translate this knowledge into improved patient care through the development of novel therapeutics and a clinical understanding of how genetic variation influences human physiology and therapeutic response.
Jacobs’s primary research efforts focus on functionally validating genetic influences on disease as potential therapeutic targets. This is accomplished through the development and use of diverse biochemical, molecular, and cellular methods and animal models to determine the function of disease-associated genes and the impact of genetic variation on gene and protein function. The goals are to identify causal genes and variants as well as the molecular, cellular and physiological mechanisms that lead to disease, as these could represent important therapeutic targets for those with or at risk for developing type 2 diabetes.
Prior to joining the Broad Institute in 2010, Jacobs completed her postdoctoral work in the laboratory of Laura Attardi at the Stanford University School of Medicine’s Department of Radiation Oncology. Jacobs received her bachelor’s degree in biological sciences from Northwestern University and earned a Ph.D. in biomedical sciences from the University of California, San Diego.
Contact Suzanne Jacobs via email at firstname.lastname@example.org.Select Publications
SIGMA Type 2 Diabetes Consortium, et al. Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico. Nature. 2014; 506(7486): 97-101.
Flannick J, Thorleifsson G, Beer NL, et al. Loss-of-function mutations in SLC30A8 protect against type 2 diabetes. Nature Genetics. 2014; 45(4): 357-363.
SIGMA Type 2 Diabetes Consortium, et al. Association of a low-frequency variant in HNF1A with type 2 diabetes in a Latino population. JAMA. 2014; 311(22): 2305-14.