Patrick McDonel is a research scientist in the laboratory of Broad Institute director Eric Lander. He takes experimental approaches to understanding how cells access developmentally important genetic information.
McDonel studies the interactions between proteins and large RNA molecules known as lincRNAs, and how those interactions influence gene expression in embryonic stem cells, both before and during cellular differentiation. He also develops new tools for high-throughput genome engineering in embryonic stem cells that will be of wide scientific interest.
McDonel joined the Broad in July 2011 after earning a Ph.D. in molecular and cell biology from University of California, Berkeley, and completing postdoctoral training at the Centre for Stem Cell Research/Department of Biochemistry, University of Cambridge (UK) and at the MRC Centre for Regenerative Medicine, Edinburgh (UK). There he was awarded an EMBO Long-Term Postdoctoral Fellowship.
McDonel P, et al. Sin3a is essential for the genome integrity and viability of pluripotent cells. Dev Biol. 2012 Mar 1;363(1):62-73.
McDonel P, Costello I, Hendrich B. Keeping things quiet: roles of NuRD and Sin3 co-repressor complexes during mammalian development. Int J Biochem Cell Biol. 2009 Jan;41(1):108-16.
McDonel P, et al. Clustered DNA motifs mark X chromosomes for repression by a dosage compensation complex. Nature. 2006 Nov 30;444(7119):614-8.
Csankovszki G, McDonel P, Meyer BJ. Recruitment and spreading of the C. elegans dosage compensation complex along X chromosomes. Science. 2004 Feb 20;303(5661):1182-5.