Nicolas Stransky is the lead computational biologist for the Cancer Cell Line Encyclopedia (CCLE) project, a collaboration between the Broad Institute and Novartis Institutes for Biomedical Research and its Genomics Institute of the Novartis Research Foundation. The goal of the CCLE effort is to conduct a detailed genetic and pharmacologic characterization of a large panel of human cancer cell lines, and to develop computational analyses that link pharmacologic vulnerabilities to genomic patterns. Stransky is also involved in a variety of cancer genome sequencing projects with the goal of discovering frequent mutations involved in cancer’s development.
Stransky joined the Broad Institute’s Cancer Program in February 2008 after completing postdoctoral work at the Institut Curie in Paris, France. His specialties include cancer genomics and genome sequencing, microarray analysis, biostatistics, and machine learning.
Stransky received his M.Sc. in biochemistry from the École Normale Supérieure in Cachan, France and his Ph.D. in oncology from the University Paris 11, Curie Institute in France.
Stransky N et al. The mutational landscape of head and neck squamous cell carcinoma. Science. 2011 Aug 26;333(6046):1157-60. Epub 2011 Jul 28.
Barretina J et al. The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity. Nature. 2012 Mar 28;483(7391):603-7. doi: 10.1038/nature11003.
Stransky N et al. Regional copy number-independent deregulation of transcription in cancer. Nat Genet. 2006 Dec;38(12):1386-96. Epub 2006 Nov 12.