Menachem Fromer is a computational biologist in the Stanley Center for Psychiatric Research at the Broad Institute. Fromer and his colleagues are attempting to discover novel disease-causing changes throughout the genomes of patients with schizophrenia and other neuropsychiatric diseases. The genes underlying susceptibility to these disorders have yet to be fully elucidated. Yet, it is clear that certain genes are either deleted or duplicated at higher frequencies in schizophrenic patients. By comparing these genetic differences in a large number of patients with schizophrenia and non-schizophrenic people, Fromer hopes to find insights into the genetics influencing the disease.
Fromer earned his academic credentials from the Hebrew University in Jerusalem. He holds B.S. degrees in the fields of biology and computer science. He subsequently was awarded his M.S. degree in computer science with specialization in genomics and bioinformatics followed by his Ph.D. degree in computational biology. In 2009, Fromer was awarded a biomedical research fellowship from Teva Pharmaceutical Industries.Select Publications
Fromer M, et al. Exposing the co-adaptive potential of protein-protein interfaces through computational sequence design. Bioinformatics. 2010 Sep 15;26(18):2266-72.
Fromer, M, et al. Design of multispecific protein sequences using probabilistic graphical modeling.
Proteins. 2010 Feb 15;78(3):530-47.
Fromer, M, et al. Tradeoff between stability and multispecificity in the design of promiscuous proteins. PLoS Comput Biol. 2009 Dec;5(12).