Mark-Anthony Bray is a computational biologist in the Imaging Platform at the Broad Institute. His research focuses on analyzing and mining data from high-content screening experiments, in which cells grown in microplates are subjected to various chemical compounds or genetic perturbations and imaged with microscopy, for the purpose of enabling basic scientific research or finding novel therapeutics.
Bray also helps develop and maintain code for the open-source software package known as CellProfiler, developed by scientists in the Broad’s Imaging Platform. CellProfiler is an image analysis tool that can quantitatively measure features of thousands of cellular images automatically.
In addition, Bray coordinates internal and external outreach and educational efforts for the platform, such as planning workshops and moderating an online forum.
Bray joined the Broad in May 2008 after completing a Ph.D. in biomedical engineering at Vanderbilt University, where he studied cardiac electrophysiology, and a postdoctoral fellowship at Harvard University, where he studied cellular bioengineering.Select Publications
Bray MA, et al. Workflow and metrics for image quality control in large-scale high-content screens. Journal of Biomolecular Screening. 2012 Feb; 17(2): 266-274.
Kamentsky L, et al. Improved structure, function and compatibility for CellProfiler: modular high-throughput image analysis software. Bioinformatics. 2011 Apr 15;27(8):1179-80.
Bray MA, Sheehy SP, Parker KK. Sarcomere alignment is regulated by myocyte shape. Cell Motility and the Cytoskeleton. 2008 Aug; 65(8): 641-651.