Ke Liu, a research scientist in the Broad Institute’s Chemical Biology Program, joined the Broad Institute in April 2010. Liu focuses on assay development for high-throughput screening, developing approaches that allow scientists to probe the biology of cells and organisms using vast libraries of small molecules. Liu’s work enables projects that take aim at a variety of diseases, including cancer and Crohn’s disease.
Liu has collaborated with colleagues on a Crohn’s disease project funded by The Leona M. And Harry B. Helmsley Charitable Trust, working on a number of assays to help identify new mechanisms and small molecules that may have therapeutic potential for this autoimmune disease. She has also taken part in a cancer cell line chemical profiling project and has developed screens for inhibitors of mutations involved in cancer.
Before joining the Broad Institute, Liu completed postdoctoral work at the National Institutes of Health Chemical Genomics Center where she also worked on assay development for high-throughput screening. Liu received her B.S. in molecular and cell biology from the University of Science and Technology of China and her Ph.D. in molecular and cell biology from Vanderbilt University.Select Publications
Liu K, et al. Yeast P4-ATPases Drs2p and Dnf1p are essential cargos of the NPFXD/Sla1p endocytic pathway. Mol Biol Cell. 2007 Feb;18(2):487-500. Epub 2006 Nov 22.
Liu K, et al. P4-ATPase requirement for AP-1/clathrin function in protein transport from the trans-Golgi network and early endosomes. Mol Biol Cell. 2008 Aug;19(8):3526-35. Epub 2008 May 28.
Natarajan P, Liu K, et al. Regulation of a Golgi flippase by phosphoinositides and an ArfGEF. Nat Cell Biol. 2009 Dec;11(12):1421-6. Epub 2009 Nov 8.
Liu K, et al. A multiplex calcium assay for identification of GPCR agonists and antagonists. Assay Drug Dev Technol. 2010 Jun;8(3):367-79.
Marugan J, Liu K, et al. Identification of Functionally Selective Small Molecule Antagonists of the Neuropeptide-S Receptor: Naphthopyranopyrimidines. Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-. 2009 Feb 13 [updated 2010 Sep 2].