Jonathan Goldberg is an associated scientist in the Genome Sequencing and Analysis Program at the Broad Institute of MIT and Harvard. He is currently working as a research associate at the Harvard T. H. Chan School of Public Health Department of Immunological and Infectious Diseases. His primary areas of expertise are in computational biology and genome annotation of eukaryotic pathogens.
At present, Goldberg is putting his skills to work in collaboration with experimental biologists in Manoj Duraisingh’s lab at the HSPH to apply computational tools toward understanding the biology of Plasmodium parasites, the causative agents of malaria. The Duraisingh lab collaborates extensively with the Broad Institute on genomic sequencing projects and RNAi screens on cultured red blood cells exposed to parasites. Goldberg’s focus is providing analysis to elucidate signaling circuits that control parasite DNA replication inside host red blood cells. He also helps lab members leverage proteomics, a technique which quantifies proteins with high-throughput, to identify proteins on the surface of host red blood cells (and their precursors) that parasites may use to gain entry into cells. He is also assisting lab members in a comparative study on the genomes of laboratory strains and field isolates of Plasmodium knowlesi, a macaque parasite of Southeast Asia that may jump to humans and cause serious illness.
Goldberg received his bachelor’s degree in chemistry from CUNY-Hunter College and went on to obtain his Ph.D. in comparative biochemistry from the University of California at Berkeley, where he studied enzyme mechanisms. Postdoctoral work at Stanford University’s Program for Genetic Medicine, where he studied protein folding and stability and protein-protein interactions, was followed by a research scientist position at the Boston Biomedical Research Institute, where he studied signal transduction in Dictyostelium. He joined the Broad Institute in 2008 and began his collaborative work with HSPH in 2014.
Contact Jonathan Goldberg via email at email@example.com.Select Publications
Egan ES, Jiang RH, Moechtar MA et al. Malaria. A forward genetic screen identifies erythrocyte CD55 as essential for Plasmodium falciparum invasion. Science. 2015; 348(6235), 711-714.
Perlin MH, Amselem J, Fontanillas E et al. Sex and parasites: genomic and transcriptomic analysis of Microbotryum lychnidis-dioicae, the biotrophic and plant-castrating anther smut fungus. BMC Genomics. 2015; 16, 461.
Desjardins, CA, Sanscrainte ND, Goldberg JM et al. Contrasting host-pathogen interactions and genome evolution in two generalist and specialist microsporidian pathogens of mosquitoes. Nature Communications. 2015; 6, 7121.
Smith JL, Goldberg JM, Grossman AD. Complete Genome Sequences of Bacillus subtilis subsp. subtilis Laboratory Strains JH642 (AG174) and AG1839. Genome Announc. 2014; 3, 2(4), e00663-14.
Goldberg JM, Griggs AD, Smith JL et al. Kinannote, a computer program to identify and classify members of the eukaryotic protein kinase superfamily. Bioinformatics. 2013; 29(19), 2387-2394.