Jonathan Goldberg is a bioinformatics scientist in the Genome Sequencing and Analysis Program at the Broad Institute. He and his fellow researchers help annotate newly sequenced genomes at the Broad, which means they identify and describe the genomes’ working parts. After scientists run an organism’s DNA through sequencing machinery, the resulting fragments of sequence are assembled into a full genome. But they are still just a string of nucleotides, or letters — As, Gs, Cs, and Ts. Goldberg’s team uses computational tools to determine what proteins — the workhorses of the cell — are encoded by the string of nucleotides. The researchers carefully monitor the quality of their protein predictions and submit them to Genbank, a database of genetic sequences that are freely available to the public and the scientific community. Goldberg is also interested in the in-depth annotation of genes belonging to the protein kinase superfamily, which regulates many aspects of cell biology, and he has provided protein kinase analysis for several recent projects.
Goldberg earned his Ph.D. in comparative biochemistry from UC Berkeley where he studied enzyme mechanisms. He later conducted postdoctoral research in Stanford University’s Program for Genetic Medicine, where he studied protein folding and stability, and protein-protein interactions. Before joining the Broad in 2007, Goldberg served as a research scientist at Boston Biomedical Research Institute, where he studied protein kinase molecular biology and bioinformatics.Select Publications
Rhind N, et al. Comparative Functional Genomics of the Fission Yeasts. Science. 2011 Apr 21. [Epub ahead of print]
Stajich JE, et al. Insights into evolution of multicellular fungi from the assembled chromosomes of the mushroom Coprinopsis cinerea (Coprinus cinereus). Proc Natl Acad Sci USA. 2010 Jun 29;107(26):11889-94.
Goldberg JM, et al. The dictyostelium kinome--analysis of the protein kinases from a simple model organism. PLoS Genet. 2006 Mar;2(3):e38.