Jon Madison is a group leader and research scientist in the Stanley Center for Psychiatric Research at the Broad Institute. His group uses a variety of approaches to understand the molecular and cellular basis of psychiatric disease.
He and his fellow researchers are using genetic reprogramming techniques to study the genetics of psychiatric diseases like bipolar disorder. In addition, Madison studies the functions of genes and proteins involved in these diseases through the use of both RNAi and small molecules. The researchers hope these approaches will lead to a more comprehensive understanding of psychiatric disease and to more effective treatments.
Madison joined the Broad Institute in 2008. He earned his Ph.D in genetics at Harvard University, and conducted postdoctoral research in neurobiology at Tufts Medical School, the University of California, Berkeley, and Massachusetts General Hospital. He is a recipient of The Brain and Behavior Research Foundation (formerly NARSAD, the National Alliance for Research on Schizophrenia and Depression) 2010 Young Investigator Award.Select Publications
Kuai L, et al. AAK1 Identified as an Inhibitor of Neuregulin-1/ErbB4-Dependent Neurotrophic Factor Signaling Using Integrative Chemical Genomics and Proteomics. Chemistry & Biology, 2011 July 29; 18(7):891-906.
Kuai L, et al. Chemical genetics identifies small-molecule modulators of neuritogenesis involving neuregulin-1/ErbB4 signaling. ACS Chem Neurosci. 2010 Jan 28;1(4):325-342.
Mao Y, et al. Disrupted in schizophrenia 1 regulates neuronal progenitor proliferation via modulation of GSK3ß/ß-catenin signaling. Cell. 2009 Mar 20;136(6):1017-31.