Jaime Cheah is a research scientist in the Chemical Biology Program who works on the National Cancer Institute–sponsored Cancer Target Discovery and Development (CTD2) Cell Line Profiling project. This project involves profiling cancer cell lines with known genetic information against highly specific small molecule probes, measuring cell viability, and then correlating the cancer cell genetics to compound sensitivity. The hope is one day to link genetically matched cancer patients to drugs that might yield better treatment responses.
Cheah received a B.S. in biochemistry from McGill University and a Ph.D. in biochemistry, cellular and molecular biology, with a concentration in neuroscience, from Johns Hopkins School of Medicine. She was a post-doctoral fellow at Novartis Institutes for BioMedical Research.Select Publications
Cheah JH et al. NMDA receptor-nitric oxide transmission mediates neuronal iron homeostasis via the GTPase Dexras1. Neuron 2006 Aug 17;51(4):431-40.
Hara MR, Cheah JH, et al. S-nitrosylated GAPDH initiates apoptotic cell death by nuclear translocation following Siah1 binding. Nat Cell Biol. 2005 Jul;7(7):665-74.
Dinkova-Kostova AT, Cheah J et al. Phenolic Michael reaction acceptors: combined direct and indirect antioxidant defenses against electrophiles and oxidants. Med Chem. 2007 May;3(3):261-8.