Isabel Latorre oversees the management of a multi-investigator program aimed at integrating information from human disease genetics with novel approaches in functional genomics and chemical biology. One focus of that mission is to make progress toward treatments for Crohn’s disease and type 1 diabetes.
Latorre joined the Broad Institute in 2010 as a project manager in the Medical and Population Genetics Program. With Ramnik Xavier, she is involved in projects that build deep collaborations across the Broad and its affiliates, including the Chemical Biology Program within the Broad and clinical associate members at Massachusetts General Hospital.
After completing an M.S. in plant biology at the University of Illinois at Urbana-Champaign, she received a Ph.D. in molecular virology and microbiology at Baylor College of Medicine. As part of her doctoral work, she generated and characterized mouse models to better understand the role of MAGUK proteins in cancer. For her postdoctoral work, she switched model organisms to C. elegans in the Ahringer laboratory at the Wellcome Trust Gurdon Institute in the University of Cambridge, UK. She focused on understanding the relationships between worm chromatin complexes whose homologs are human oncogenes and tumor suppressors, while working as part of the modENCODE consortium.
Gerstein MB et al. Integrative analysis of the Caenorhabditis elegans genome by the modENCODE project. Science 2010 Dec 24;330(6012):1775-87. Epub 2010 Dec 22.
Latorre IJ, et al. Oncogenic function for the Dlg1 mammalian homolog of the Drosophila discs-large tumor suppressor. EMBO J. 2006 Mar 22;25(6):1406-17. Epub 2006 Mar 2.
Latorre I, et al. Viral oncoprotein-induced mislocalization of select PDZ proteins disrupts tight junctions and causes polarity defects in epithelial cells. J Cell Sci. 2005 Sep 15;118(Pt 18):4283-93. Epub 2005 Sep 1.