Colm O’Dushlaine is a research scientist in the Stanley Center for Psychiatric Research at the Broad Institute investigating the genetics of neuropsychiatric disorders. He and his colleagues analyze data from large-scale, population-based medical sequencing studies in order to assess how genetic variation contributes to the risk of schizophrenia and biopolar disorder. To do this, O’Dushlaine investigates statistical genetics of genome-wide association studies and next-generation sequence data, and pathway-based analyses. The aim is to find promising gene targets that hopefully will lead to therapeutic or treatment interventions for people with schizophrenia and bipolar disorder.
His research interests also include the study of population genetics – the study of how the human genome can shift as populations move and migrate.
O’Dushlaine earned his undergraduate degree in Biotechnology from the National University of Ireland, Maynooth. He was awarded a Ph.D. in bioinformatics from the Royal College of Surgeons in Ireland and then took up a position as a post-doctoral research fellow at Trinity College in Dublin, Ireland. O’Dushlaine performed additional post-doctoral research at Massachusetts General Hospital in Boston before moving to the Stanley Center in May 2011.Select Publications
O’Dushlaine CT, et al. Population structure and genome-wide patterns of variation in Ireland and Britain. European Journal of Human Genetics 2010 Nov;18(11):1248-54.
O’Dushlaine CT, et al. Molecular pathways involved in neuronal cell adhesion and membrane scaffolding contribute to schizophrenia and bipolar disorder susceptibility. Mol Psychiatry. 2011 Mar;16(3):286-92.
O’Dushlaine CT, et al. The SNP ratio test: pathway analysis of genome-wide association datasets.
Bioinformatics. 2009 Oct 15;25(20):2762-3.