Chuck Epstein manages the Broad’s Epigenomics Program, which studies modifications to DNA and the protein scaffold that supports it. These modifications affect gene expression and play a crucial role in cellular differentiation during development and in disease.
At the Broad, Epstein oversees the chromatin immunoprecipitation (ChIP) lab, and coordinates efforts between the ChIP, DNA methylation, and informatics groups. He works closely with principal investigators to make sure that key scientific objectives are supported and capabilities are in place.
In addition, he is responsible for compliance and deliverables under the NIH-funded Roadmap Epigenomics Mapping Center Program and the ENCODE project, ensuring communication between the larger objectives of these projects and local activities to meet project goals.
Epstein recently spearheaded the development of a laboratory information management system (LIMS) to support the needs of the Epigenomics Program. He is currently working to expand the reach of the i nitiative into new areas and promoting automation of lab and data quality assurance processes.
Epstein joined the Broad in July 2008 after working as principal research investigator (focused on biomarker discovery) with Sanofi-Aventis Pharmaceuticals. Prior to that, he completed his Ph.D. at The Rockefeller University and conducted postdoctoral research with Arnold J. Levine (Princeton) and Ron Butow (Southwestern Medical Center).Select Publications
Ernst J, et al. Mapping and analysis of chromatin state dynamics in nine human cell types. Nature. 2011 May 5;473(7345):43-9. Epub 2011 Mar 23.
Harris RA, et al. Comparison of sequencing-based methods to profile DNA methylation and identification of monoallelic epigenetic modifications. Nat Biotechnol. 2010 Oct;28(10):1097-105. Epub 2010 Sep 19.
Ram O et al. Combinatorial patterning of chromatin regulators uncovered by genome-wide location analysis in human cells. Cell. 2011 Dec:147(7):1628-39.