Christina Cuomo leads the Fungal Genome Sequencing and Analysis Group at the Broad Institute. She oversees projects that target important human and agricultural fungal pathogens and represent fungal diversity. The group compares the genomes of groups of fungi to look for differences that correlate with differences in phenotypes such as virulence, lifestyle, or host niche. Cuomo’s group also sequences multiple strains of important pathogens to examine population diversity and gene expression changes during infection or other conditions.
As part of her current work under the Fungal Genome Initiative at the Broad, Cuomo leads analysis of a wide diversity of animal and plant pathogens, with the goal of better understanding the genetic basis of pathogenicity. Animal pathogens include three major groups of human pathogens: Candida albicans, Cryptococcus neoformans, and the dimorphic fungi. Plant pathogens include the wheat rust fungi (Puccinia sp) that cause current agricultural epidemics and Microbotryum violaceum, a model for studying host shifts, pathogenicity, and sex chromosome evolution.
Cuomo joined the Whitehead Institute/MIT Center for Genome Research, now part of the Broad Institute, in 2002. She now works in the Broad’s Genome Sequencing and Analysis Program.
She received her A.B. in biology from Bryn Mawr College and Ph.D. in genetics from Harvard University.
Cuomo CA, et al. Microsporidia genome analysis reveals evolutionary strategies for obligate intracellular growth. Genome Research 2012. Dec;22(12):2478-88.
Desjardins CA, et al. Comparative genomic analysis of human fungal pathogens causing paracoccidiomycosis. PLoS Genetics 2011 Oct;7(10):e1002345.
Duplessis S, Cuomo CA, et al. Obligate biotrophy features unraveled by the genomic analysis of rust fungi. PNAS 2011. May 31;108(22):9166-71.