Chris Desjardins

Chris Desjardins is a computational biologist working in the Genome Sequencing and Analysis Program at the Broad Institute of MIT and Harvard. In this role, he works with external collaborators and internal research scientists to analyze data from large-scale efforts to sequence the genomes and transcriptomes of pathogenic organisms.

His projects cover a wide range of microorganisms, including fungi, filarial nematodes, and bacteria, and he is currently focused on using genomic and transcriptomic data to better understand the genetic basis of virulence and antibiotic resistance. Additionally, Desjardins develops bioinformatics software pipelines, with a particular emphasis on functional genomics and evolution, to enable high-throughput computational analysis of these large data sets. Recently, Desjardins has begun working with the Broad Technology Labs to develop pipelines for analysis of transcriptional data from single cells.

Desjardins joined the Broad in 2010 after completing a Ph.D. in entomology at the University of Maryland and conducting postdoctoral research at The Institute for Genomic Research and the University of Rochester. His primary areas of expertise are in bioinformatics, genomics, and evolutionary biology.

Contact Chris Desjardins via email at

Select Publications

Desjardins, CA, Sanscrainte ND, Goldberg JM et al. Contrasting host-pathogen interactions and genome evolution in two generalist and specialist microsporidian pathogens of mosquitoes. Nature Communications. 2015; 6, 7121.

Desjardins, CA, Cerqueira, GC, Goldberg, JM et al. Genomics of Loa loa, a Wolbachia-free filarial parasite of humans. Nature Genetics. 2013; 45(5), 495-500.

Cuomo CA*, Desjardins CA*, Bakowski MA* et al. Microsporidian genome analysis reveals evolutionary strategies for obligate intracellular growth. Genome Research. 2012; 22(12), 2478-2488. 

Desjardins, CA, Champion, MD, Holder, JW et al. Comparative genomic analysis of human fungal pathogens causing paracoccidioidomycosis. PLOS Genetics. 2011; 7(10): e1002345.

*co-first authors

Last updated date: October 2015