Angela Koehler is an Investigator in the Broad Institute’s Chemical Biology Program. Her research group aims to discover and develop functional small-molecule probes of transcriptional regulators, including chromatin modifying enzymes and oncogenic transcription factors. Validated probes may be used to advance the understanding of transcription in development and disease. Selected probes may be developed into imaging agents, diagnostic tools, or therapeutic leads.
Koehler received her B.A. in biochemistry and molecular biology from Reed College in 1997. There she worked under the guidance of Arthur Glasfeld on structural and biochemical studies of proteins that recognize tRNA and DNA. In 2003, she received her Ph.D. in chemistry from Harvard University where she worked with Broad Institute core member Stuart Schreiber to develop novel technologies for identifying and characterizing interactions between proteins and small molecules. Upon graduation, she became an institute fellow in the Chemical Biology Program at the Broad Institute and a group leader for the NCI Initiative for Chemical Genetics. She is currently an investigator in the Chemical Biology Program and a project leader in the NCI Cancer Target Discovery and Development (CTD2) Center at the Broad Institute, aimed at targeting causal cancer genes with small molecules.
Kemp MK et al., A novel HDAC inhibitor with a hydroxy-pyrimidine scaffold. Bioorg. Med. Chem. Lett., 21, 4164-4169, 2011. PMCID in progress
Koehler AN. A complex task? Direct modulation of transcription factors with small molecules. Curr. Opin. Chem. Biol., 14, 331-340, 2010.
Schmitz, K, et al. Detecting binding interactions using microarrays of natural product extracts. J. Am. Chem. Soc., 129, 11346-11347, 2007.
Bradner JE, et al. A robust small-molecule microarray platform for screening cell lysates. Chem. Biol. 13, 493-504, 2006.