Amedeo Vetere is a research scientist in the Center for the Science of Therapeutics (CSofT) Chemical Biology Program at the Broad Institute, where he works on the beta-cell biology and regenerative medicine project. His research activity is focused towards small-molecule therapeutics for the treatment of type 1 diabetes, with a key goal of developing in vivo therapies that increase the number or function of pancreatic beta cells.
Vetere graduated from the School of Biological Sciences at the University of Naples (Italy) "Federico II" in 1989. From there, he became a research associate at the Stazione Zoologica "A. Dohrn" in Naples, working on understanding the physiological role of D-aspartic acid. In 1993 he was awarded a Technology Training Grant from the Italian Ministry for University and Research that allowed him to acquire competencies in the field of biomaterials at the Department of Biochemistry, Biophysics, and Macromolecular Chemistry at the University of Trieste (Italy), which later led to his undertaking a doctoral program in biochemistry there. Vetere’s doctorate focused on specific biotechnological methods to obtain biologically relevant oligosaccharides. He later joined the University of Trieste’s faculty as an assistant professor of biochemistry in the School of Medicine, where he continued researching the development of novel biocompatible polymer-based tools for biomedical applications.
In 2004, Vetere expanded a growing interest in beta-cell biology during a sabbatical at the Joslin Diabetes Center in Boston. He was subsequently awarded the EASD/ADA Transatlantic Fellowship to extend his stay for a full year at the Joslin Diabetes Center, and he stayed on as a visiting scientist for an additional six years, focusing his scientific interests towards the molecular mechanisms that control beta-cell proliferation.
Vetere left the Joslin Diabetes Center in 2010 to join the Broad Institute. His principal areas of expertise include beta-cell biology, chemical biology, probe discovery, assay development, and molecular biology.
Contact Amedeo Vetere via email at firstname.lastname@example.org.Select Publications
Chou DH-C, Vetere, A, Choudhary, A et al. Kinase-independent small-molecule inhibition of JAK-STAT signaling. J. Am. Chem. Soc., 2015; 137(24), 7929-7934.
Burns SM, Vetere A, Walpita D, et al. High-Throughput Luminescent Reporter of Insulin Secretion for Discovering Regulators of Pancreatic Beta-Cell Function. Cell Metabolism. 2015; 21, 126-137.
Vetere A, Choudhary A, Burns SM et al. Targeting the pancreatic beta cell to treat diabetes. Nature Rev. Drug Disc. 2014; 13, 278-289.