Abigail Manson McGuire

Abigail Manson McGuire is a senior computational biologist I in the Genome Sequencing and Analysis Program at the Broad Institute of MIT and Harvard. She conducts comparative analysis of whole genome sequences, with a focus on understanding the evolution of virulence and antibiotic resistance. She has worked on a wide variety of bacteria, including Mycobacterium tuberculosis, Enterococcus, Fusobacterium, and E. coli, with particular emphasis on the evolution of drug resistance and virulence factors.

A computational biologist, McGuire previously completed a comparative analysis of tuberculosis genomes. Before that, she studied alternative splicing of genetic material and worked on predicting noncoding RNAs — RNA molecules that are not translated into proteins — in the fungus Aspergillus.

McGuire joined the Broad as postdoc after receiving bachelor’s degrees in physics and mathematics at Washington University and a Ph.D. in biophysics at Harvard University.

Contact Abigail McGuire via email at amcguire@broadinstitute.org.

Select Publications

Manson McGuire A, Cochrane K, Griggs A, et al. Evolution of invasion in a diverse set of Fusobacterium. mBio. 2014;5(6):e01864-14.

Lebreton F, van Schaik W, Manson McGuire A, et al. Emergence of epidemic multi-drug resistant Enterococcus faecium from animal and commensal strains. mBio. 2013; 4(4): e00534-13.

Cohen KA, Abeel T, Manson McGuire A, et al. Evolution of extensively drug-resistant tuberculosis over four decades revealed by whole genome sequencing of Mycobacterium tuberculosis from KwaZulu-Natal, South Africa. PloS Med. 2015;12(9):e1001880.

Last updated date: January 2016