Abigail McGuire works in the Microbial Genome Analysis group in the Genome Sequencing and Analysis Program, conducting comparative analyses of whole genome sequences as part of the Human Microbiome Project. Within that ambitious effort to describe the enormous number and diversity of microbes that live in the human body, she focuses on Fusobacteria.
A computational biologist, McGuire previously completed a comparative analysis of tuberculosis genomes. Before that, she studied alternative splicing of genetic material and worked on predicting noncoding RNAs – RNA molecules that are not translated into proteins -- in the fungus aspergillus.
McGuire joined the Broad as postdoc after receiving bachelor’s degrees in physics and mathematics at Washington University and a Ph.D. in biophysics at Harvard University.Select Publications
McGuire AM et al. Comparative analysis of Mycobacterium and related Actinomycetes yields insight into the evolution of Mycobacterium tuberculosis pathogenesis. BMC Genomics 2012; 13:120.
McGuire AM, Galagan JE. Conserved secondary structures in Aspergillus. PLoS One 2008 Jul 30;3(7):e2812.
McGuire AM et al. Cross-kingdom patterns of alternative splicing and splice recognition. Genome Biology 2008;9(3):R50.