Inflammatory Bowel Disease

The Project

The primary goal of this project is to identify the genes which predispose humans to developing the inflammatory bowel diseases (IBD) known as Crohn's Disease (CD) and Ulcerative colitis (UC).

The IBD project is a collaborative effort between our group at the Whitehead Institute/MIT Center for Genome Research and multiple canadian centers, situated in Toronto (Mount Sinai Hospital Lunenfeld Research Institute and the Hospital for Sick Children), Montreal (Montreal General Hospital, Royal Victoria Hospital, and Jewish General Hospital), Chicoutimi (Complexe Hospitalier de la Sagamie), and Halifax (Dalhousie University).

We have been performing a genome-wide scan on more than 150 sibpair families and have reported the results from our linkage analyses:

• Genomewide Search in Canadian Families with Inflammatory Bowel Disease Reveals Two Novel Susceptibility Loci
• Rioux JD, Silverberg MS, Daly MJ, Steinhart AH, McLeod RS, Griffiths AM, Green T, Brettin TS, Stone V, Bull SB, Bitton A, Williams CN,Greenberg GR, Cohen Z, Lander ES, Hudson TJ, Siminovitch KA Am. J. Hum. Genet., (In Press; June 2000)
• Absence of Linkage Between Inflammatory Bowel Disease and Selected Loci on Chromosomes 3, 7, 12, and 16
• Rioux JD, Daly MJ, Green T, Stone V, Lander ES, Hudson TJ, Steinhart AH, Bull S, Cohen Z, Greenberg G, Griffiths A,McLeod R, Silverberg M, Williams CN, Siminovitch KA. Gasterontology 1998;115:1062-1065

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  General Information

  Relevant OMIM links:
  IBD 1
  IBD 2
  Ulcerative Colitis

  Other linkage reports:

  Evidence of linkage of the inflammatory bowel disease susceptibility locus on chromosome 16 (IBD1) to ulcerative colitis.
  Mirza MM, Lee J, Teare D, Hugot JP, Laurent-Puig P, Colombel JF, Hodgson SV, Thomas G, Easton DF, Lennard-Jones JE, Mathew CG J Med Genet. 1998 Mar; 35(3): 218-221.

  Identification of novel susceptibility loci for inflammatory bowel disease on chromosomes 1p, 3q, and 4q: evidence for epistasis between 1p and IBD1.
  Cho JH, Nicolae DL, Gold LH, Fields CT, LaBuda MC, Rohal PM, Pickles MR, Qin L, Fu Y, Mann JS, Kirschner BS, Jabs EW, Weber J, Hanauer SB, Bayless TM, Brant SR. Proc Natl Acad Sci U S A 1998 Jun 23;95(13):7502-7507.

  Susceptibility locus for inflammatory bowel disease on chromosome 16 has a role in Crohn's disease, but not in ulcerative colitis.
  Ohmen JD, Yang HY, Yamamoto KK, Zhao HY, Ma Y, Bentley LG, Huang Z, Gerwehr S, Pressman S,McElree C, Targan S, Rotter JI, Fischel-Ghodsian N. Hum Mol Genet 1996 Oct;5(10):1679-1683.

  Mapping of a susceptibility locus for Crohn's disease on chromosome 16.
  Hugot JP, Laurent-Puig P, Gower-Rousseau C, Olson JM, Lee JC, Beaugerie L, Naom I, Dupas JL,Van Gossum A, Orholm M, Bonaiti-Pellie C, Weissenbach J, Mathew CG, Lennard-Jones JE, Cortot A,Colombel JF, Thomas G. Nature 1996 Feb 29;379(6568):821-823.

  Two stage genome-wide search in inflammatory bowel disease provides evidence for susceptibility loci on chromosomes 3, 7 and 12.
  Satsangi J, Parkes M, Louis E, Hashimoto L, Kato N, Welsh K, Terwilliger JD, Lathrop GM, Bell JI, Jewell DP. Nat Genet 1996 Oct;14(2):199-202.

  Relevant links for general information:

  Crohn's and Colitis Foundation of America

  Crohn's and Colitis Foundation of Canada

  National Institute of Diabetes and Digestive and Kidney Diseases

  Crohn's Disease Resource Center