An Introduction to Computational Genomics

for Infectious Disease




This course will serve as an introduction to computational genomics methods with selected applications to the study of infectious disease organisms.  It will include both lectures at the HSPH and computational “labs” at the Broad Institute.


Class Schedule:  January 16-26, 2007


Lectures: Tuesdays & Thursdays


Labs: Wednesdays & Fridays


11:00 a.m. - 12:30 p.m.


1:00 p.m. – 3:00 p.m.


Harvard School of Public Health: FXB-301

The François-Xavier Bagnoud Center, Room 301

651 Huntington Avenue

Boston, MA 02155

Broad Institute: Olympus Room

First floor of Broad Main Lobby

7 Cambridge Center

Cambridge, MA 02142







Teaching Assistants:


Lab Instructors:






Lecture (HSPH)

Laboratory (Broad)

Basic Sequence Analysis and Annotation

1/16/07 (Tuesday)


1/17/07 (Wednesday)

Notes Data Launch Argo

Classification and Clustering of Microarray Data

1/18/07 (Thursday)



1/19/07 (Friday)

Data Support Vector Machines

Matlab Training Opportunity

Motif Prediction and Antigen Prediction

1/23/07 (Tuesday)


1/24/07 (Wednesday)

Notes Data

History of Motif Prediction

Motif Prediction Overview

Common Research Strategies

Iron Regulation in TB

Steady State Metabolic Modeling

1/25/07 (Thursday)


1/26/07 (Friday)

Notes Data

Manual for CellNetAnalyzer


TB Mycolic Acid Model





Sponsored by the Broad Institute & HSPH Dept. of Immunology and Infectious Disease