Dengue Virus Portal
Dengue Virus Classification
ICTV Group: Unassigned
Baltimore Group: Group IV ((+)ssRNA, no DNA stage)
Species: Dengue Virus
Dengue virus (DEN), a category-A pathogen, is a significant threat to public health world wide. The virus is transmitted to humans by the mosquitoes Aedes aegypti and Ae. albopictus. The incidence of dengue fever (DF), dengue hemorrhagic fever (DHF), and dengue shock syndrome (DSS) are rapidly increasing, and more than 2.5 billion people live in regions endemic for the disease. Presently approximately 50-100 million cases of DF occur yearly with more than 500,000 resulting in severe and potentially fatal forms of the disease (DHF & DSS). Several factors contribute to the threat posed by dengue. Most significant are lack of cross-reactive immunity for the four DEN serotypes (DEN-1, DEN-2, DEN-3, and DEN-4), hyperendemic circulation of the four different serotypes in the same geographical area, frequent worldwide travel, high population density, and lack of effective mosquito control programs. Other socioeconomic factors only amplify the challenge of dengue control.
Photo Credits and Captions
The images on this page are, from left to right:
- Photo of Aedes Aegypti from the CDC's Public Health Image Library; photographer: Jim Gathany.
- Mature Dengue-2 virus particles replicating in five-day-old tissue culture cells. Electron micrograph, CDC
- This image shows the immature dengue particle. Notable are the 60 protein "spikes" which jut from the surface, making the immature particle far less smooth than the mature form. One spike is circled for reference. Knowledge of how the immature particle develops into the mature, infectious dengue virus could be important to developing antiviral medicines. (Purdue Structural Virology)
- The structure of the mature dengue virus particle was determined in 2002 by Michael Rossmann and Richard Kuhn's team. The virus' surface is unusually smooth and its membrane is completely enclosed by a protein shell. The protein is color-coded blue, green and yellow to show the three specific domains of the protein. The protein shell serves as a cage for the genetic material inside. (Purdue Structural Virology)
- An image of the dengue virus, based on cryoelectron microscopy and image reconstruction (Purdue Structural Virology)
This sequencing project was supported by the National Institute of Allergy and Infectious Disease, National Institutes of Health funded Genome Sequencing Center for Infectious Diseases at the Broad Institute.