The Purpose of the TB Systems Biology Program

The Tuberculosis Systems Biology Program will experimentally map and computationally model the molecular pathways of M. tuberculosis under conditions relevant to TB pathogenesis. To do so, we have established a collaborative network that will perform systematic profiling using ChIP-seq, transcriptomics, proteomics, glycomics, metabolomics, and lipidomics during both in vitro and in vivo growth and will integrated these data into predictive computational models of the M. tuberculosis regulatory and metabolic networks.

All data and software developed for this project will be made publicly available.

The Tuberculosis Systems Biology Program is one of four centers established by the National Institute of Allergy and Infectious Diseases (NIAID) to develop Systems Biology Approaches to Infectious Disease.