Comparative Analysis
Specific Polymorphisms of KZN Strains versus F11 Reference Strain
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The Venn diagram illustrates the number of differences, including intergenic and coding differences, between each strain and F11. These mutations were identified by comparing both Solexa sequence reads and draft ABI contigs for the 3 KZN clinical TB isolates. Click on the sections in the diagram to see the polymorphisms in each subset. |
Drug Resistance-Associated Mutations in KZN Strains
Mutations in known drug resistance genes are shown in the table below. Amino acid coordinates from H37Rv are shown to facilitate comparison to published mutations. The H37Rv coordinates do not necessarily correspond to the position of the same amino acid in the F11 and KZN orthologous genes.
| Drug resistance | MDR | XDR |
|---|---|---|
| inh | katG S315T | katG S315T |
| inh | inhA -8TA | inhA -8TA |
| rif | rpoB D435Y | rpoB D435G |
| rif | rpoB N487S | rpoB L452P |
| rif | rpoB I1106T | |
| streptomycin | gidB Δ | gidB Δ |
| pyrazinamide | pncA A132G | pncA Δ |
| ethambutol | embB M306V | embB M306V |
| ofloxacin | gyrA A90V | |
| kanamycin | rrs A1401G |
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