Polymorphism Report: MDR-TB Strains

 

Protein-Coding Mutations: SNPs Unique to MDR
F11 Location F11 Gene (H37Rv) Mutation Annotation Base Alignment
F11 Δ DNA Protein
1005429 TBFG_10916 (Rv0897c) T271M hypothetical oxidoreductase C T
2201503 TBFG_11969 (Rv1940) G215S riboflavin biosynthesis protein ribA1 (GTP cyclohydrolase II) G A
764870 TBFG_10681 (Rv0667) D441Y DNA-directed RNA polymerase beta subunit rpoB G T
765027 TBFG_10681 (Rv0667) N493S DNA-directed RNA polymerase beta subunit rpoB A G
2303459 TBFG_12080 (Rv2043c) G132A pyrazinamidase/nicotinamidase pncA G C
4422308 TBFG_13956 (Rv3921c) I256V conserved transmembrane protein A G
2687873 TBFG_12408 (Rv2383c) P420P phenyloxazoline synthase mbtB C G
3651352 TBFG_13288 (Rv3259) P86P hypothetical protein G A
2881156 TBFG_12565 (Rv2545) P19L hypothetical protein C T

 

Protein-Coding Mutations: Indels Unique to MDR
F11 Location F11 Gene (H37Rv) Annotation Frameshift Alignment
DNA Protein
1577028 TBFG_11425 (Rv1396c) PE-PGRS family protein Yes

 

Non-Protein-Coding Mutations Unique to MDR
F11 Location Mutation Left Gene Right Gene Distance Away From: Intergenic Alignment
F11 Δ F11 (H37Rv) Annotation F11 (H37Rv) Annotation Left Direction Left Gene Right Gene Right Direction
2983290 T C TBFG_12662 (Rv2643) hypothetical protein TBFG_12663 (Rv2645) hypothetical protein 1141 150