M. tuberculosis
Gene Search
Polymorphism Report: DS/MDR/XDR-TB Strains
| Protein-Coding Mutations: SNPs Shared by DS, MDR, and XDR | ||||||||||||||||
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| F11 Location | F11 Gene (H37Rv) | Mutation | Annotation | Base | Alignment | |||||||||||
| F11 | Δ | DNA | Protein | |||||||||||||
| 983925 | TBFG_10898 (Rv0881) | W247R | hypothetical rRNA methyltransferase (rRNA methylase) | T | C |  |
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| 984185 | TBFG_10899 (Rv0882) | C46G | hypothetical protein | T | G | |
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| 995340 | TBFG_10909 (Rv0890c) | G361D | hypothetical transcriptional regulatory protein, luxR-family | G | A | |
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| 1999315 | TBFG_11786 (Rv1760) | L61S | hypothetical protein | T | C | |
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| 2001452 | TBFG_11788 (Rv1762c) | T124T | hypothetical protein | C | T | |
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| 2014485 | TBFG_11801 (Rv1773c) | A74A | hypothetical transcriptional regulatory protein | A | C | |
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| 2042914 | TBFG_11827 (Rv1796) | V312M | proline rich membrane-anchored mycosin mycP5 | G | A | |
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| 2045968 | TBFG_11829 (Rv1798) | R339R | hypothetical protein | T | C | |
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| 1043876 | TBFG_10950 (Rv0932c) | A333A | periplasmic phosphate-binding lipoprotein pstS2 | G | A | |
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| 1051509 | TBFG_10956 (Rv0938) | F516L | hypothetical ATP dependent DNA ligase | T | G | |
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| 1059498 | TBFG_10963 (Rv0946c) | L338L | glucose-6-phosphate isomerase pgi | T | G | |
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| 1061614 | TBFG_10966 (Rv0948c) | K59T | hypothetical protein | A | C | |
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| 2079828 | TBFG_11855 (Rv1825) | P181S | hypothetical protein | C | T | |
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| 2085449 | TBFG_11861 (Rv1832) | T459T | glycine dehydrogenase gcvB | G | A | |
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| 5621 | TBFG_10005 (Rv0005) | L133P | DNA gyrase subunit B gyrB | T | C | |
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| 7323 | TBFG_10005 (Rv0005) | S700S | DNA gyrase subunit B gyrB | T | C | |
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| 8141 | TBFG_10006 (Rv0006) | G247S | DNA gyrase subunit A gyrA | G | A | |
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| 15326 | TBFG_10013 (Rv0013) | L104L | anthranilate synthase component II trpG (glutamine amidotransferase) | A | G | |
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| 16156 | TBFG_10014 (Rv0014c) | P472P | transmembrane serine/threonine-protein kinase B pknB | G | T | |
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| 17709 | TBFG_10015 (Rv0015c) | S385R | transmembrane serine/threonine-protein kinase A pknA | C | G | |
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| 1074299 | TBFG_10976 (Rv0958) | L198L | hypothetical magnesium chelatase | T | C | |
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| 1076856 | TBFG_10977 (Rv0959) | G593G | hypothetical protein | T | G | |
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| 1087399 | TBFG_10990 (Rv0972c) | P59T | acyl-CoA dehydrogenase fadE12 | C | A | |
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| 1091102 | TBFG_10992 (Rv0974c) | K23E | acetyl-/propionyl-CoA carboxylase beta subunit accD2 | A | G | |
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| 1093995 | TBFG_10994 (Rv0976c) | C2R | hypothetical protein | T | C | |
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| 1121794 | TBFG_11020 (Rv1001) | T281M | arginine deiminase arcA | C | T | |
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| 2129254 | TBFG_11898 (Rv1870c) | D123G | hypothetical protein | A | G | |
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| 2137099 | TBFG_11906 (Rv1878) | S296F | glutamine synthetase glnA3 | C | T | |
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| 2142421 | TBFG_11912 (Rv1884c) | H16R | resuscitation-promoting factor rpfC | A | G | |
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| 2150034 | TBFG_11922 (Rv1894c) | V18F | hypothetical protein | G | T | |
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| 2152833 | TBFG_11926 (Rv1897c) | P89L | hypothetical protein | C | T | |
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| 2183742 | TBFG_11952 (Rv1923) | K105N | lipase lipD | A | C | |
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| 30597 | TBFG_10026 (Rv0026) | T259A | hypothetical protein | A | G | |
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| 37864 | TBFG_10034 (Rv0035) | D169H | fatty-acid-CoA ligase fadD34 | G | C | |
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| 46916 | TBFG_10041 (Rv0042c) | R131R | hypothetical transcriptional regulatory protein, marR-family | C | G | |
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| 47800 | TBFG_10042 (Rv0043c) | R134R | hypothetical transcriptional regulatory protein, gntR-family | T | C | |
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| 69129 | TBFG_10063 (Rv0064) | L136V | conserved transmembrane protein | C | G | |
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| 1148432 | TBFG_11041 (Rv1023) | R34Q | enolase eno | G | A | |
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| 1161536 | TBFG_11050 (Rv1032c) | R63L | two component system sensor histidine kinase trcS | G | T | |
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| 1166042 | TBFG_11057 (Rv1039c) | A67T | PPE family protein | G | A | |
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| 1181764 | TBFG_11074 (Rv1056) | Y123H | hypothetical protein | T | C | |
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| 2199506 | TBFG_11967 (Rv1938) | K75K | epoxide hydrolase ephB | A | G | |
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| 2200605 | TBFG_11968 (Rv1939) | V86A | hypothetical oxidoreductase | T | C | |
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| 2218898 | TBFG_11998 (Rv1967) | F15S | MCE-family protein mce3B | T | C | |
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| 2231305 | TBFG_12010 (Rv1979c) | E38D | conserved permease | G | C | |
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| 2235908 | TBFG_12014 (Rv1983) | S471P | PE-PGRS family protein | T | C | |
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| 88619 | TBFG_10080 (Rv0079) | D95H | hypothetical protein | G | C | |
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| 102321 | TBFG_10093 (Rv0092) | S536R | cation transporter ATPase A ctpA | A | C | |
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| 111494 | TBFG_10102 (Rv0101) | S454P | peptide synthetase nrp | T | C | |
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| 113972 | TBFG_10102 (Rv0101) | F1280L | peptide synthetase nrp | T | C | |
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| 144940 | TBFG_10120 (Rv0119) | E269D | fatty-acid-CoA ligase fadD7 | G | C | |
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| 147791 | TBFG_10121 (Rv0120c) | L39L | elongation factor G (EF-G) fusA2 | G | C | |
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| 148082 | TBFG_10122 (Rv0121c) | A133T | hypothetical protein | G | A | |
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| 165981 | TBFG_10139 (Rv0138) | V115I | hypothetical protein | G | A | |
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| 1235116 | TBFG_11125 (Rv1104) | S17G | hypothetical para-nitrobenzyl esterase | A | G | |
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| 1236263 | TBFG_11127 (Rv1105) | Y62Y | hypothetical para-nitrobenzyl esterase | C | T | |
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| 179257 | TBFG_10152 (Rv0151c) | N123K | PE family protein | C | A | |
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| 196838 | TBFG_10167 (Rv0166) | D510D | fatty-acid-CoA ligase fadD5 | C | T | |
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| 1268148 | TBFG_11158 (Rv1135A) | Y23C | hypothetical acetyl-CoA acetyltransferase (acetoacetyl-CoA thiolase) | A | G | |
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| 1294090 | TBFG_11186 (Rv1161) | H1000R | respiratory nitrate reductase alpha subunit narG | A | G | |
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| 1299182 | TBFG_11190 (Rv1165) | L417L | GTP-binding translation elongation factor typA | G | A | |
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| 243853 | TBFG_10207 (Rv0205) | V51A | conserved transmembrane protein | T | C | |
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| 245037 | TBFG_10208 (Rv0206c) | L867P | transmembrane transport protein mmpL3 | T | C | |
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| 245229 | TBFG_10208 (Rv0206c) | R803P | transmembrane transport protein mmpL3 | G | C | |
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| 265472 | TBFG_10223 (Rv0221) | S363W | hypothetical protein | C | G | |
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| 286194 | TBFG_10238 (Rv0236c) | T326A | conserved transmembrane protein | A | G | |
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| 288222 | TBFG_10240 (Rv0237) | A240V | lipoprotein lpqI | C | T | |
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| 294329 | TBFG_10247 (Rv0244c) | D541A | acyl-CoA dehydrogenase fadE5 | A | C | |
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| 1328489 | TBFG_11208 (Rv1184c) | M296I | hypothetical protein | G | T | |
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| 1328930 | TBFG_11208 (Rv1184c) | Q149Q | hypothetical protein | G | A | |
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| 1336300 | TBFG_11213 (Rv1189) | A148A | alternative RNA polymerase sigma factor sigI | C | A | |
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| 1338025 | TBFG_11215 (Rv1191) | G110G | hypothetical protein | A | C | |
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| 1358529 | TBFG_11236 (Rv1212c) | I299M | hypothetical glycosyl transferase | C | G | |
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| 1374503 | TBFG_11251 (Rv1227c) | Q30R | hypothetical protein | A | G | |
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| 313233 | TBFG_10265 (Rv0261c) | P418L | integral membrane nitrite extrusion protein narK3 (nitrite facilitator) | C | T | |
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| 326356 | TBFG_10274 (Rv0270) | A491A | fatty-acid-CoA ligase fadD2 | T | C | |
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| 328214 | TBFG_10275 (Rv0271c) | V189I | acyl-CoA dehydrogenase fadE6 | G | A | |
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| 374346 | TBFG_10310 (Rv0303) | S1482S | PPE family protein | A | G | |
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| 1387894 | TBFG_11265 (Rv1240) | G306R | malate dehydrogenase mdh | G | C | |
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| 1394294 | TBFG_11274 (Rv1248c) | S842S | 2-oxoglutarate dehydrogenase sucA | G | C | |
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| 1394295 | TBFG_11274 (Rv1248c) | S842Y | 2-oxoglutarate dehydrogenase sucA | C | A | |
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| 1406799 | TBFG_11281 (Rv1255c) | I119V | hypothetical transcriptional regulatory protein | A | G | |
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| 1429477 | TBFG_11302 (Rv1276c) | Q79E | hypothetical protein | C | G | |
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| 390433 | TBFG_10324 (Rv0319) | G69D | pyrrolidone-carboxylate peptidase pcp | G | A | |
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| 395994 | TBFG_10332 (Rv0327c) | S378G | cytochrome P450 135A1 cyp135A1 | A | G | |
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| 406444 | TBFG_10343 (Rv0338c) | P826P | hypothetical iron-sulfur-binding reductase | C | T | |
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| 407000 | TBFG_10343 (Rv0338c) | R641H | hypothetical iron-sulfur-binding reductase | G | A | |
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| 1443917 | TBFG_11312 (Rv1286) | S415L | bifunctional enzyme cysN/cysC: sulfate adenyltransferase subunit 1 + adenylylsulfate kinase | C | T | |
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| 1447471 | TBFG_11316 (Rv1290c) | S448S | hypothetical protein | A | G | |
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| 1455309 | TBFG_11322 (Rv1295) | A282A | threonine synthase thrC | T | C | |
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| 1496506 | TBFG_11357 (Rv1325c) | A86A | PE-PGRS family protein | G | A | |
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| 460200 | TBFG_10386 (Rv0381c) | L264L | hypothetical protein | G | A | |
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| 469264 | TBFG_10391 (Rv0386) | C896R | hypothetical transcriptional regulatory protein, luxR/uhpA-family | T | C | |
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| 480852 | TBFG_10404 (Rv0399c) | S292W | lipoprotein lpqK | C | G | |
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| 482802 | TBFG_10405 (Rv0400c) | T41N | acyl-CoA dehydrogenase fadE7 | C | A | |
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| 488579 | TBFG_10409 (Rv0404) | P478H | fatty-acid-CoA ligase fadD30 | C | A | |
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| 504705 | TBFG_10420 (Rv0415) | V130F | thiamine biosynthesis oxidoreductase thiO | G | T | |
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| 518295 | TBFG_10430 (Rv0425c) | T66N | metal cation transporter P-type ATPase ctpH | C | A | |
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| 518549 | TBFG_10431 (Rv0426c) | T190T | hypothetical protein | A | C | |
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| 1525545 | TBFG_11383 (Rv1353c) | G47R | hypothetical transcriptional regulatory protein | G | C | |
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| 1550871 | TBFG_11402 (Rv1373) | E173E | glycolipid sulfotransferase | G | A | |
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| 536950 | TBFG_10449 (Rv0444c) | E3E | hypothetical protein | G | A | |
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| 538864 | TBFG_10453 (Rv0447c) | G271G | cyclopropane-fatty-acyl-phospholipid synthase ufaA1 | G | A | |
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| 547852 | TBFG_10459 (Rv0453) | V504M | PPE family protein | G | A | |
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| 561670 | TBFG_10474 (Rv0467) | D325D | isocitrate lyase icl | C | T | |
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| 562221 | TBFG_10475 (Rv0468) | E53A | 3-hydroxybutyryl-CoA dehydrogenase fadB2 | A | C | |
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| 575637 | TBFG_10491 (Rv0483) | M253I | lipoprotein lprQ | G | A | |
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| 1596356 | TBFG_11445 (Rv1416) | G115G | riboflavin synthase beta subunit ribH | T | C | |
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| 1596794 | TBFG_11446 (Rv1417) | Q102* | hypothetical protein | C | T | |
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| 1596795 | TBFG_11446 (Rv1417) | *102S | hypothetical protein | A | C | |
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| 1629381 | TBFG_11474 (Rv1441c) | L116P | oxpP cycle protein opcA | T | C | |
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| 1655943 | TBFG_11491 (Rv1463) | A197A | ATP-binding protein ABC transporter | C | T | |
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| 1670651 | TBFG_11504 (Rv1475c) | A11A | iron-regulated aconitate hydratase acn | G | C | |
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| 1684126 | TBFG_11520 (Rv1490) | V56V | hypothetical membrane protein | C | G | |
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| 1696842 | TBFG_11532 (Rv1501) | S106G | hypothetical protein | A | G | |
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| 641099 | TBFG_10557 (Rv0546c) | E33E | hypothetical protein | A | G | |
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| 649471 | TBFG_10564 (Rv0554) | S259S | peroxidase bpoC (non-haem peroxidase) | C | T | |
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| 678901 | TBFG_10588 (Rv0578c) | A82T | PE-PGRS family protein | G | A | |
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| 684010 | TBFG_10595 (Rv0584) | F518F | hypothetical protein | C | T | |
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| 1714707 | TBFG_11552 (Rv1518) | E143Q | hypothetical protein | G | C | |
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| 1760157 | TBFG_11583 (Rv1551) | M25I | acyltransferase plsB1 | G | T | |
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| 1766892 | TBFG_11589 (Rv1557) | G171R | transmembrane transport protein mmpL6 | G | A | |
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| 1775996 | TBFG_11596 (Rv1564c) | G82S | maltooligosyltrehalose synthase treX | G | A | |
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| 708823 | TBFG_10621 (Rv0610c) | A105A | hypothetical protein | A | G | |
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| 716001 | TBFG_10631 (Rv0620) | H20Y | galactokinase galK | C | T | |
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| 725764 | TBFG_10641 (Rv0630c) | A826A | exonuclease V beta subunit recB | G | A | |
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| 739938 | TBFG_10655 (Rv0642c) | N162S | methoxy mycolic acid synthase 4 mmaA4 | A | G | |
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| 755708 | TBFG_10668 (Rv0655) | V144A | ribonucleotide transport ATP-binding protein ABC transporter mkl | T | C | |
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| 757959 | TBFG_10671 (Rv0658c) | R71H | conserved integral membrane protein | G | A | |
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| 1779950 | TBFG_11599 (Rv1567c) | C41G | hypothetical membrane protein | T | G | |
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| 1781851 | TBFG_11601 (Rv1569) | A171G | 8-amino-7-oxononanoate synthase bioF1 | C | G | |
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| 1783195 | TBFG_11603 (Rv1571) | L7L | hypothetical protein | T | C | |
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| 1786998 | TBFG_11607 (Rv1591) | P13L | hypothetical protein | C | T | |
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| 1792418 | TBFG_11611 (Rv1595) | T408I | L-aspartate oxidase nadB | C | T | |
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| 1795197 | TBFG_11615 (Rv1599) | V81A | histidinol dehydrogenase hisD | T | C | |
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| 1797097 | TBFG_11616 (Rv1600) | S271A | histidinol-phosphate aminotransferase hisC1 | T | G | |
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| 1800677 | TBFG_11621 (Rv1605) | G145V | cyclase hisF | G | T | |
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| 1801339 | TBFG_11622 (Rv1606) | T99I | phosphoribosyl-AMP 1,6-cyclohydrolase hisI | C | T | |
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| 1806148 | TBFG_11627 (Rv1611) | R183Q | indole-3-glycerol phosphate synthase trpC | G | A | |
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| 1808646 | TBFG_11630 (Rv1614) | S29C | prolipoprotein diacylglyceryl transferases lgt | A | T | |
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| 1810995 | TBFG_11631 (Rv1615) | A118T | hypothetical membrane protein | G | A | |
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| 1833544 | TBFG_11649 (Rv1633) | H360R | excinuclease ABC subunit B (helicase) uvrB | A | G | |
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| 764916 | TBFG_10681 (Rv0667) | L456S | DNA-directed RNA polymerase beta subunit rpoB | T | C | |
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| 788342 | TBFG_10698 (Rv0684) | T699T | elongation factor G (EF-G) fusA1 | C | G | |
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| 795883 | TBFG_10706 (Rv0692) | T98A | hypothetical protein | A | G | |
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| 1841854 | TBFG_11654 (Rv1638) | S908I | excinuclease ABC subunit A (DNA-binding ATPase) uvrA | G | T | |
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| 1843575 | TBFG_11656 (Rv1639c) | W92* | hypothetical protein | G | A | |
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| 1857457 | TBFG_11667 (Rv1650) | Q770L | phenylalanyl-tRNA synthetase beta subunit pheT | A | T | |
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| 1858461 | TBFG_11668 (Rv1651c) | T146T | PE-PGRS family protein | A | G | |
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| 1880463 | TBFG_11680 (Rv1662) | V1124M | polyketide synthase pks8 | G | A | |
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| 1882800 | TBFG_11681 (Rv1663) | R300P | polyketide synthase pks17 | G | C | |
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| 1890574 | TBFG_11685 (Rv1666c) | D57N | hypothetical macrolide-transport ATP-binding protein ABC transporter | G | A | |
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| 818510 | TBFG_10735 (Rv0721) | A105V | 30S ribosomal protein S5 rpsE | C | T | |
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| 821725 | TBFG_10739 (Rv0725c) | G197R | hypothetical protein | G | C | |
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| 857338 | TBFG_10773 (Rv0758) | G358G | two component system response sensor kinase membrane associated phoR | A | C | |
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| 865151 | TBFG_10783 (Rv0768) | S124S | aldehyde dehydrogenase NAD dependent aldA | C | T | |
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| 866855 | TBFG_10784 (Rv0769) | R192R | hypothetical dehydrogenase/reductase | C | T | |
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| 867673 | TBFG_10785 (Rv0770) | F184L | hypothetical dehydrogenase/reductase | T | C | |
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| 1924481 | TBFG_11718 (Rv1703c) | K194T | hypothetical catechol-O-methyltransferase | A | C | |
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| 1949275 | TBFG_11743 (Rv1726) | G280R | hypothetical oxidoreductase | G | C | |
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| 1962343 | TBFG_11756 (Rv1738) | M55K | hypothetical protein | T | A | |
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| 1964544 | TBFG_11758 (Rv1740) | A47E | hypothetical protein | C | A | |
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| 1965340 | TBFG_11760 (Rv1742) | I156I | hypothetical protein | T | A | |
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| 880928 | TBFG_10798 (Rv0783c) | I461I | multi-drug resistance integral membrane efflux protein emrB | C | A | |
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| 888423 | TBFG_10806 (Rv0790c) | F83S | hypothetical protein | T | C | |
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| 888544 | TBFG_10806 (Rv0790c) | E43K | hypothetical protein | G | A | |
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| 921904 | TBFG_10840 (Rv0825c) | T54R | hypothetical protein | C | G | |
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| 924515 | TBFG_10845 (Rv0830) | A12V | hypothetical protein | C | T | |
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| 3019795 | TBFG_12705 (Rv2690c) | A457V | conserved alanine, valine and leucine rich integral membrane protein | C | T | |
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| 3041565 | TBFG_12730 (Rv2716) | A147T | hypothetical protein | G | A | |
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| 3063023 | TBFG_12750 (Rv2737c) | Q119Q | recombinase A recA | A | G | |
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| 3972320 | TBFG_13556 (Rv3523) | G3E | lipid carrier protein or keto acyl-CoA thiolase ltp3 | G | A | |
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| 3980898 | TBFG_13564 (Rv3531c) | N277N | hypothetical protein | C | T | |
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| 3986738 | TBFG_13568 (Rv3535c) | G183R | hypothetical acetaldehyde dehydrogenase (acetaldehyde dehydrogenase [acetylating]) | G | A | |
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| 3997154 | TBFG_13578 (Rv3545c) | I359T | cytochrome P450 125 cyp125 | T | C | |
|
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| 4018643 | TBFG_13597 (Rv3564) | H206Y | acyl-CoA dehydrogenase fadE33 | C | T | |
|
|||||||||
| 4024731 | TBFG_13603 (Rv3570c) | V107V | hypothetical oxidoreductase | C | T | |
|
|||||||||
| 3072309 | TBFG_12761 (Rv2748c) | A718G | cell division transmembrane protein ftsK | C | G | |
|
|||||||||
| 3073570 | TBFG_12761 (Rv2748c) | M298V | cell division transmembrane protein ftsK | A | G | |
|
|||||||||
| 3077779 | TBFG_12765 (Rv2752c) | P123L | hypothetical protein | C | T | |
|
|||||||||
| 3107561 | TBFG_12800 (Rv2787) | R166G | conserved alanine rich protein | A | G | |
|
|||||||||
| 4046735 | TBFG_13624 (Rv3591c) | F30S | hypothetical hydrolase | T | C | |
|
|||||||||
| 4058426 | TBFG_13635 (Rv3603c) | A179A | conserved alanine and leucine rich protein | A | G | |
|
|||||||||
| 4061014 | TBFG_13638 (Rv3606c) | L172P | 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase folK | T | C | |
|
|||||||||
| 4063658 | TBFG_13642 (Rv3610c) | A669A | cell division protein ftsH (membrane-bound protease) | G | C | |
|
|||||||||
| 4085243 | TBFG_13664 (Rv3633) | A150A | hypothetical protein | G | A | |
|
|||||||||
| 3142311 | TBFG_12837 (Rv2823c) | G367G | hypothetical protein | T | C | |
|
|||||||||
| 4097602 | TBFG_13675 (Rv3646c) | M887L | DNA topoisomerase I topA (omega-protein) | A | C | |
|
|||||||||
| 4111306 | TBFG_13690 (Rv3660c) | P282S | hypothetical protein | C | T | |
|
|||||||||
| 4140998 | TBFG_13716 (Rv3685c) | R243R | cytochrome P450 137 cyp137 | G | C | |
|
|||||||||
| 4146357 | TBFG_13722 (Rv3691) | A306G | hypothetical protein | C | G | |
|
|||||||||
| 4149582 | TBFG_13725 (Rv3694c) | V178V | conserved transmembrane protein | G | A | |
|
|||||||||
| 4150658 | TBFG_13726 (Rv3695) | H151R | hypothetical protein | A | G | |
|
|||||||||
| 3181222 | TBFG_12874 (Rv2858c) | A380A | aldehyde dehydrogenase aldC | G | A | |
|
|||||||||
| 3207086 | TBFG_12900 (Rv2886c) | H292H | hypothetical resolvase | T | C | |
|
|||||||||
| 3207504 | TBFG_12900 (Rv2886c) | V153A | hypothetical resolvase | T | C | |
|
|||||||||
| 3207963 | TBFG_12901 (Rv2887) | S2G | hypothetical transcriptional regulatory protein | A | G | |
|
|||||||||
| 3226769 | TBFG_12919 (Rv2905) | H205Y | lipoprotein lppW | C | T | |
|
|||||||||
| 3235149 | TBFG_12929 (Rv2915c) | V354A | hypothetical protein | T | C | |
|
|||||||||
| 3237721 | TBFG_12930 (Rv2916c) | R32C | signal recognition particle protein ffh | C | T | |
|
|||||||||
| 4154037 | TBFG_13729 (Rv3698) | Y182D | hypothetical protein | T | G | |
|
|||||||||
| 4155105 | TBFG_13730 (Rv3699) | P21A | hypothetical protein | C | G | |
|
|||||||||
| 4160497 | TBFG_13735 (Rv3704c) | T231A | glutamate-cysteine ligase gshA | A | G | |
|
|||||||||
| 4161530 | TBFG_13736 (Rv3705c) | A145D | hypothetical protein | C | A | |
|
|||||||||
| 4163649 | TBFG_13739 (Rv3707c) | G131G | hypothetical protein | C | T | |
|
|||||||||
| 4166389 | TBFG_13741 (Rv3709c) | Q32H | aspartokinase ask | A | C | |
|
|||||||||
| 4169280 | TBFG_13743 (Rv3711c) | G151R | DNA polymerase III epsilon subunit dnaQ | G | C | |
|
|||||||||
| 4176247 | TBFG_13751 (Rv3719) | R310T | hypothetical protein | G | C | |
|
|||||||||
| 4190265 | TBFG_13760 (Rv3728) | R798C | conserved two-domain membrane protein | C | T | |
|
|||||||||
| 1476104 | TBFG_14046 (MTB000019) | T492C | ribosomal RNA 16S rrs | T | C | |
N/A | |||||||||
| 2257657 | TBFG_12035 (Rv2003c) | R6R | hypothetical protein | A | G | |
|
|||||||||
| 2262104 | TBFG_12038 (Rv2006) | D617N | trehalose-6-phosphate phosphatase otsB1 | G | A | |
|
|||||||||
| 2276984 | TBFG_12057 (no ortholog) | V118A | hypothetical protein | T | C | |
|
|||||||||
| 3242315 | TBFG_12933 (Rv2919c) | D97D | nitrogen regulatory protein P-II glnB | T | C | |
|
|||||||||
| 3250176 | TBFG_12939 (Rv2924c) | E256D | formamidopyrimidine-DNA glycosylase fpg | A | C | |
|
|||||||||
| 3272853 | TBFG_12947 (Rv2933) | N1899S | phenolpthiocerol synthesis type-I polyketide synthase ppsC | A | G | |
|
|||||||||
| 3284673 | TBFG_12950 (Rv2936) | S329S | daunorubicin-dim-transport ATP-binding protein ABC transporter drrA | A | C | |
|
|||||||||
| 3296199 | TBFG_12955 (Rv2941) | L464L | fatty-acid-CoA ligase fadD28 | G | C | |
|
|||||||||
| 3323029 | TBFG_12972 (Rv2958c) | V149I | hypothetical glycosyl transferase | G | A | |
|
|||||||||
| 3326102 | TBFG_12976 (Rv2962c) | W165* | hypothetical glycosyl transferase | G | A | |
|
|||||||||
| 4238648 | TBFG_13813 (Rv3779) | A221A | conserved alanine and leucine rich transmembrane protein | A | G | |
|
|||||||||
| 2330281 | TBFG_12096 (Rv2059) | V166I | hypothetical protein | G | A | |
|
|||||||||
| 3344989 | TBFG_12992 (Rv2977c) | E91D | thiamine-monophosphate kinase thiL | G | C | |
|
|||||||||
| 3352324 | TBFG_12999 (Rv2984) | L253F | polyphosphate kinase ppk | G | C | |
|
|||||||||
| 3363635 | TBFG_13009 (Rv2994) | S220P | conserved integral membrane protein | T | C | |
|
|||||||||
| 3368869 | TBFG_13013 (Rv2998) | P116A | hypothetical protein | C | G | |
|
|||||||||
| 3378614 | TBFG_13023 (Rv3008) | K88E | hypothetical protein | A | G | |
|
|||||||||
| 4308632 | TBFG_13859 (Rv3825c) | V1325V | polyketide synthase pks2 | T | G | |
|
|||||||||
| 4310794 | TBFG_13859 (Rv3825c) | A605T | polyketide synthase pks2 | G | A | |
|
|||||||||
| 4312176 | TBFG_13859 (Rv3825c) | G144A | polyketide synthase pks2 | G | C | |
|
|||||||||
| 4312481 | TBFG_13859 (Rv3825c) | S42S | polyketide synthase pks2 | C | T | |
|
|||||||||
| 4329047 | TBFG_13877 (Rv3843c) | V184A | conserved transmembrane protein | T | C | |
|
|||||||||
| 4329115 | TBFG_13877 (Rv3843c) | A161A | conserved transmembrane protein | T | C | |
|
|||||||||
| 2384068 | TBFG_12143 (Rv2111c) | L39L | hypothetical protein | G | C | |
|
|||||||||
| 2385179 | TBFG_12144 (Rv2112c) | A318A | hypothetical protein | A | C | |
|
|||||||||
| 2385180 | TBFG_12144 (Rv2112c) | A318V | hypothetical protein | C | T | |
|
|||||||||
| 2394245 | TBFG_12154 (Rv2122c) | A88D | phosphoribosyl-ATP pyrophosphohydrolase hisE | C | A | |
|
|||||||||
| 2404095 | TBFG_12160 (Rv2129c) | N219S | hypothetical oxidoreductase | A | G | |
|
|||||||||
| 2404697 | TBFG_12160 (Rv2129c) | I18I | hypothetical oxidoreductase | C | T | |
|
|||||||||
| 2425721 | TBFG_12183 (Rv2153c) | V398L | UDP-N-acetylglucosamine-N-acetylmuramyl- (pentapeptide)pyrophosphoryl-undecaprenol-N- acetylglucosamine transferase murG | G | C | |
|
|||||||||
| 2427080 | TBFG_12184 (Rv2154c) | R468R | cell division protein ftsW | C | T | |
|
|||||||||
| 2431772 | TBFG_12187 (Rv2157c) | V265A | UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate-D-alanyl-D-alanyl ligase murF | T | C | |
|
|||||||||
| 2436385 | TBFG_12191 (Rv2161c) | G105A | hypothetical protein | G | C | |
|
|||||||||
| 3399876 | TBFG_13045 (Rv3029c) | T235T | electron transfer flavoprotein beta subunit fixA | C | G | |
|
|||||||||
| 3404172 | TBFG_13048 (Rv3032) | Q310L | hypothetical transferase | A | T | |
|
|||||||||
| 3413661 | TBFG_13058 (Rv3042c) | V404V | phosphoserine phosphatase serB2 | G | C | |
|
|||||||||
| 3426501 | TBFG_13069 (Rv3053c) | A56A | glutaredoxin-like electron transport protein nrdH | G | C | |
|
|||||||||
| 3431752 | TBFG_13076 (Rv3059) | V189I | cytochrome P450 136 cyp136 | G | A | |
|
|||||||||
| 3434880 | TBFG_13077 (Rv3060c) | T10T | hypothetical transcriptional regulatory protein, gntR-family | G | A | |
|
|||||||||
| 3448060 | TBFG_13089 (Rv3072c) | D6D | hypothetical protein | C | T | |
|
|||||||||
| 3453206 | TBFG_13095 (Rv3078) | R30R | hydroxylaminobenzene mutase hab | C | A | |
|
|||||||||
| 4354636 | TBFG_13900 (Rv3865) | D24G | hypothetical protein | A | G | |
|
|||||||||
| 4362688 | TBFG_13906 (Rv3871) | S288P | hypothetical protein | T | C | |
|
|||||||||
| 4363446 | TBFG_13906 (Rv3871) | S540S | hypothetical protein | C | G | |
|
|||||||||
| 4367671 | TBFG_13911 (Rv3876) | S554S | conserved proline and alanine rich protein | C | T | |
|
|||||||||
| 4374162 | TBFG_13916 (Rv3881c) | P255Q | conserved alanine and glycine rich protein | C | A | |
|
|||||||||
| 4376069 | TBFG_13917 (Rv3882c) | I118V | hypothetical protein | A | G | |
|
|||||||||
| 4386755 | TBFG_13925 (Rv3890c) | A87T | Esat-6 like protein esxC (Esat-6 like protein 11) | G | A | |
|
|||||||||
| 4398535 | TBFG_13935 (Rv3900c) | P260R | conserved alanine rich protein | C | G | |
|
|||||||||
| 4401158 | TBFG_13938 (Rv3903c) | G760G | hypothetical alanine and proline rich protein | T | C | |
|
|||||||||
| 4402207 | TBFG_13938 (Rv3903c) | N411D | hypothetical alanine and proline rich protein | A | G | |
|
|||||||||
| 4403758 | TBFG_13940 (Rv3905c) | S93S | Esat-6 like protein esxF | G | C | |
|
|||||||||
| 4412390 | TBFG_13945 (Rv3910) | A930V | conserved transmembrane protein | C | T | |
|
|||||||||
| 2450174 | TBFG_12204 (Rv2176) | E11K | transmembrane serine/threonine-protein kinase L pknL | G | A | |
|
|||||||||
| 2450293 | TBFG_12204 (Rv2176) | I50M | transmembrane serine/threonine-protein kinase L pknL | A | G | |
|
|||||||||
| 2473961 | TBFG_12225 (Rv2197c) | P112S | conserved transmembrane protein | C | T | |
|
|||||||||
| 2482773 | TBFG_12234 (Rv2206) | K2K | conserved transmembrane protein | A | G | |
|
|||||||||
| 2498642 | TBFG_12247 (Rv2219) | A88T | conserved transmembrane protein | G | A | |
|
|||||||||
| 3463434 | TBFG_13102 (Rv3085) | L251V | hypothetical short-chain type dehydrogenase/reductase | C | G | |
|
|||||||||
| 3466750 | TBFG_13105 (Rv3088) | A216E | hypothetical protein | C | A | |
|
|||||||||
| 3470255 | TBFG_13107 (Rv3090) | D94G | hypothetical alanine and valine rich protein | A | G | |
|
|||||||||
| 3508781 | TBFG_13151 (Rv3130c) | A237P | hypothetical protein | G | C | |
|
|||||||||
| 2531065 | TBFG_12274 (Rv2245) | G269S | 3-oxoacyl-[acyl-carrier protein] synthase 1 kasA | G | A | |
|
|||||||||
| 2537149 | TBFG_12279 (Rv2250c) | A119T | hypothetical transcriptional regulatory protein | G | A | |
|
|||||||||
| 2549748 | TBFG_12291 (Rv2264c) | R250L | conserved proline rich protein | G | T | |
|
|||||||||
| 2558505 | TBFG_12299 (Rv2273) | R86R | conserved transmembrane protein | T | C | |
|
|||||||||
| 3522629 | TBFG_13163 (Rv3142c) | S14C | hypothetical protein | C | G | |
|
|||||||||
| 3538026 | TBFG_13178 (Rv3157) | T258A | NADH dehydrogenase I chain M nuoM (NADH-ubiquinone oxidoreductase chain M) | A | G | |
|
|||||||||
| 3546316 | TBFG_13185 (Rv3164c) | R238Q | methanol dehydrogenase transcriptional regulatory protein moxR3 | G | A | |
|
|||||||||
| 3550527 | TBFG_13190 (Rv3169) | N56S | hypothetical protein | A | G | |
|
|||||||||
| 3555385 | TBFG_13195 (Rv3174) | L42R | hypothetical short-chain type dehydrogenase/reductase | T | G | |
|
|||||||||
| 2574193 | TBFG_12314 (Rv2291) | L78L | thiosulfate sulfurtransferase sseB | T | C | |
|
|||||||||
| 2580191 | TBFG_12321 (Rv2298) | L108M | hypothetical protein | C | A | |
|
|||||||||
| 2612501 | TBFG_12351 (Rv2328) | Q328R | PE family protein | A | G | |
|
|||||||||
| 2612972 | TBFG_12352 (Rv2329c) | A426A | nitrite extrusion protein 1 narK1 (nitrite facilitator 1) | T | C | |
|
|||||||||
| 2628267 | TBFG_12363 (Rv2339) | L926L | transmembrane transport protein mmpL9 | A | G | |
|
|||||||||
| 3576165 | TBFG_13215 (Rv3195) | G13S | hypothetical protein | G | A | |
|
|||||||||
| 3576555 | TBFG_13215 (Rv3195) | N143D | hypothetical protein | A | G | |
|
|||||||||
| 3588730 | TBFG_13224 (Rv3201c) | P24P | hypothetical ATP-dependent DNA helicase | T | C | |
|
|||||||||
| 3592399 | TBFG_13227 (Rv3203) | Y37H | lipase lipV | T | C | |
|
|||||||||
| 3599948 | TBFG_13237 (Rv3211) | V129V | ATP-dependent RNA helicase rhlE | G | A | |
|
|||||||||
| 3609010 | TBFG_13246 (Rv3220c) | H101Q | two component sensor kinase | T | G | |
|
|||||||||
| 3612495 | TBFG_13252 (Rv3224A) | S28I | hypothetical protein | G | T | |
|
|||||||||
| 2655894 | TBFG_12387 (Rv2361c) | T290T | long-chain (C50) Z-isoprenyl diphosphate synthase | T | C | |
|
|||||||||
| 2663150 | TBFG_12394 (Rv2368c) | D40D | phoH-like protein phoH1 (phosphate starvation-inducible protein psiH) | T | C | |
|
|||||||||
| 2667938 | TBFG_12399 (Rv2374c) | M151V | heat shock protein transcriptional repressor hrcA | A | G | |
|
|||||||||
| 2673006 | TBFG_12404 (Rv2379c) | L792P | peptide synthetase mbtF | T | C | |
|
|||||||||
| 2678443 | TBFG_12405 (Rv2380c) | R705R | peptide synthetase mbtE | C | G | |
|
|||||||||
| 3645735 | TBFG_13283 (Rv3254) | T95P | hypothetical protein | A | C | |
|
|||||||||
| 3655170 | TBFG_13292 (Rv3263) | G72G | hypothetical DNA methylase (methyltransferase) | C | T | |
|
|||||||||
| 3655408 | TBFG_13292 (Rv3263) | G152S | hypothetical DNA methylase (methyltransferase) | G | A | |
|
|||||||||
| 2709747 | TBFG_12426 (Rv2398c) | P236A | sulfate-transport integral membrane protein ABC transporter cysW | C | G | |
|
|||||||||
| 2769274 | TBFG_12479 (Rv2454c) | S49S | hypothetical oxidoreductase beta subunit | C | T | |
|
|||||||||
| 3700659 | TBFG_13331 (Rv3302c) | S167G | glycerol-3-phosphate dehydrogenase glpD2 | A | G | |
|
|||||||||
| 3707627 | TBFG_13337 (Rv3308) | L369L | phosphomannomutase pmmB | G | A | |
|
|||||||||
| 3729532 | TBFG_13363 (Rv3331) | L39P | sugar-transport integral membrane protein sugI | T | C | |
|
|||||||||
| 3734919 | TBFG_13368 (Rv3335c) | D3E | conserved integral membrane protein | C | G | |
|
|||||||||
| 2782045 | TBFG_12489 (Rv2464c) | A99T | hypothetical DNA glycosylase | G | A | |
|
|||||||||
| 2806676 | TBFG_12506 (Rv2485c) | N210S | carboxylesterase lipQ | A | G | |
|
|||||||||
| 2808660 | TBFG_12508 (Rv2487c) | P240L | PE-PGRS family protein | C | T | |
|
|||||||||
| 2813551 | TBFG_12510 (Rv2488c) | D216G | hypothetical transcriptional regulatory protein, luxR-family | A | G | |
|
|||||||||
| 2821795 | TBFG_12516 (Rv2494) | P56P | hypothetical protein | C | T | |
|
|||||||||
| 2826021 | TBFG_12520 (Rv2498c) | V158V | citrate lyase beta subunit citE | G | A | |
|
|||||||||
| 2828279 | TBFG_12523 (Rv2501c) | G640G | acetyl-/propionyl-coenzyme A carboxylase alpha subunit accA1 : biotin carboxylase + biotin carboxyl carrier protein | C | T | |
|
|||||||||
| 3761991 | TBFG_13380 (Rv3347c) | K535R | PPE family protein | A | G | |
|
|||||||||
| 3762122 | TBFG_13380 (Rv3347c) | F491F | PPE family protein | T | C | |
|
|||||||||
| 3784029 | TBFG_13395 (Rv3359) | C74G | hypothetical oxidoreductase | T | G | |
|
|||||||||
| 3801315 | TBFG_13411 (Rv3375) | S74A | amidase amiD (acylamidase) | T | G | |
|
|||||||||
| 2858007 | TBFG_12545 (Rv2524c) | L1548L | fatty acid synthase fas | G | C | |
|
|||||||||
| 2885229 | TBFG_12573 (Rv2552c) | D35D | shikimate 5-dehydrogenase aroE | T | C | |
|
|||||||||
| 2897314 | TBFG_12584 (Rv2564) | Q219R | glutamine-transport ATP-binding protein ABC transporter glnQ | A | G | |
|
|||||||||
| 3844988 | TBFG_13449 (Rv3415c) | *276Q | hypothetical protein | T | C | |
|
|||||||||
| 3863578 | TBFG_13468 (Rv3431c) | V91V | transposase | A | G | |
|
|||||||||
| 3869936 | TBFG_13473 (Rv3436c) | I222I | glucosamine-fructose-6-phosphate aminotransferase [isomerizing] glmS | C | T | |
|
|||||||||
| 2916780 | TBFG_12598 (Rv2578c) | L23L | hypothetical protein | G | A | |
|
|||||||||
| 2920946 | TBFG_12602 (Rv2582) | Q272Q | peptidyl-prolyl-cis-trans-isomerase B ppiB | A | G | |
|
|||||||||
| 2945635 | TBFG_12624 (Rv2605c) | G275G | acyl-CoA thioesterase II tesB2 | G | T | |
|
|||||||||
| 3896937 | TBFG_13502 (Rv3465) | I131M | dTDP-4-dehydrorhamnose 3,5-epimerase rmlC | A | G | |
|
|||||||||
| 3906529 | TBFG_13512 (Rv3477) | N28N | PE family protein | C | T | |
|
|||||||||
| 3915883 | TBFG_13519 (Rv3484) | A151A | hypothetical protein cpsA | G | C | |
|
|||||||||
| 3952333 | TBFG_13544 (Rv3510c) | Y200H | hypothetical protein | T | C | |
|
|||||||||
| 2977341 | TBFG_12655 (Rv2637) | I147V | transmembrane protein dedA | A | G | |
|
|||||||||
| 2983443 | TBFG_12663 (Rv2645) | T2A | hypothetical protein | A | G | |
|
|||||||||
| 3016046 | TBFG_12702 (Rv2687c) | R220W | hypothetical antibiotic-transport integral membrane leucine and valine rich protein ABC transporter | C | T | |
|
|||||||||
| Protein-Coding Mutations: Indels Shared by DS, MDR, and XDR | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| F11 Location | F11 Gene (H37Rv) | Annotation | Frameshift | Alignment | ||||||||||
| DNA | Protein | |||||||||||||
| 36579 | TBFG_10031 (Rv0032) | 8-amino-7-oxononanoate synthase bioF2 | Yes | |
|
|||||||||
| 69592 | TBFG_10063 (Rv0064) | conserved transmembrane protein | Yes | |
|
|||||||||
| 1201475 | TBFG_11091 (Rv1073) | hypothetical protein | Yes | |
|
|||||||||
| 773726 | TBFG_10684 (Rv0670) | endonuclease IV end | Yes | |
|
|||||||||
| 863000 | TBFG_10781 (Rv0766c) | cytochrome P450 123 cyp123 | Yes | |
|
|||||||||
| 3240993 | TBFG_12932 (Rv2918c) | PII uridylyltransferase glnD | Yes | |
|
|||||||||
| 4339105 | TBFG_13890 (Rv3854c) | monooxygenase ethA | Yes | |
|
|||||||||
| 2376697 | TBFG_12135 (Rv2101) | helicase helZ | Yes | |
|
|||||||||
| 3436863 | TBFG_13078 (Rv3061c) | acyl-CoA dehydrogenase fadE22 | Yes | |
|
|||||||||
| 2619756 | TBFG_12358 (Rv2334) | cysteine synthase A cysK1 | Yes | |
|
|||||||||
| 2727755 | TBFG_12443 (Rv2415c) | hypothetical protein | No | |
|
|||||||||
| 2791176 | TBFG_12498 (Rv2474c) | hypothetical protein | No | |
|
|||||||||
| Non-Protein-Coding Mutations Shared by DS, MDR, and XDR | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| F11 Loc. | Mutation | Left Gene | Right Gene | Distance Away From: | Intergenic Alignment | ||||||
| F11 | Δ | F11 (H37Rv) | Annotation | F11 (H37Rv) | Annotation | Left Dir. | Left Gene | Right Gene | Right Dir. | ||
| 1802 | T | C | TBFG_10001 (Rv0001) | chromosomal replication initiator protein dnaA | TBFG_10002 (Rv0002) | DNA polymerase III beta subunit dnaN (DNA nucleotidyltransferase) | → | 177 | 351 | → | |
| 1843 | A | G | TBFG_10001 (Rv0001) | chromosomal replication initiator protein dnaA | TBFG_10002 (Rv0002) | DNA polymerase III beta subunit dnaN (DNA nucleotidyltransferase) | → | 218 | 310 | → | |
| 1922 | G | T | TBFG_10001 (Rv0001) | chromosomal replication initiator protein dnaA | TBFG_10002 (Rv0002) | DNA polymerase III beta subunit dnaN (DNA nucleotidyltransferase) | → | 297 | 231 | → | |
| 27564 | C | G | TBFG_10022 (Rv0022c) | transcriptional regulatory protein whib-like whiB5 | TBFG_10023 (Rv0023) | hypothetical transcriptional regulatory protein | ← | 21 | 132 | → | |
| 41358 | G | A | TBFG_10036 | conserved integral membrane protein | TBFG_10037 (Rv0038) | hypothetical protein | ← | 55 | 47 | → | |
| 149459 | C | T | TBFG_10124 (Rv0123) | hypothetical protein | TBFG_10125 (Rv0124) | PE-PGRS family protein | → | 99 | 168 | → | |
| 169010 | T | G | TBFG_10143 (Rv0142) | hypothetical protein | TBFG_10144 (Rv0143c) | conserved transmembrane protein | → | 57 | 10 | ← | |
| 296234 | T | C | TBFG_10247 (Rv0244c) | acyl-CoA dehydrogenase fadE5 | TBFG_10248 (Rv0245) | hypothetical oxidoreductase | ← | 284 | 88 | → | |
| 302977 | C | T | TBFG_10254 (Rv0251c) | heat shock protein hsp (heat-stress-induced ribosome-binding protein A) | TBFG_10255 (Rv0252) | nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] nirB | ← | 8 | 206 | → | |
| 303008 | C | A | TBFG_10254 (Rv0251c) | heat shock protein hsp (heat-stress-induced ribosome-binding protein A) | TBFG_10255 (Rv0252) | nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] nirB | ← | 39 | 175 | → | |
| 756563 | A | C | TBFG_10668 (Rv0655) | ribonucleotide transport ATP-binding protein ABC transporter mkl | TBFG_10669 (Rv0656c) | hypothetical protein | → | 206 | 182 | ← | |
| 773424 | T | G | TBFG_10683 (Rv0669c) | hypothetical hydrolase | TBFG_10684 (Rv0670) | endonuclease IV end | ← | 66 | 129 | → | |
| 990388 | T | C | TBFG_10905 (no ortholog) | hypothetical protein | TBFG_10906 (no ortholog) | hypothetical protein | → | 28 | 111 | → | |
| 1167172 | G | C | TBFG_11058 (Rv1040c) | PE family protein | TBFG_11059 (Rv1041c) | transposase | ← | 28 | 1168 | ← | |
| 1209039 | T | C | TBFG_11097 (Rv1079) | cystathionine gamma-synthase metB | TBFG_11098 (Rv1080c) | transcription elongation factor greA | → | 36 | 35 | ← | |
| 1275774 | C | T | TBFG_11167 (Rv1144) | hypothetical short-chain type dehydrogenase/reductase | TBFG_11168 (Rv1144) | hypothetical protein | → | 102 | 26 | ← | |
| 1479823 | G | A | TBFG_14046 (MTB000019) | rrs | TBFG_11343 (Rv1316c) | methylated-DNA-protein- cysteine methyltransferase ogt |
→ | 2674 | 1078 | ← | |
| 1546675 | C | T | TBFG_11398 (Rv1367c) | hypothetical protein | TBFG_11399 (Rv1368) | lipoprotein lprF | ← | 259 | 44 | → | |
| 1713436 | T | G | TBFG_11550 (Rv1516c) | hypothetical sugar transferase | TBFG_11551 (Rv1517) | hypothetical protein | ← | 260 | 72 | → | |
| 1837671 | T | C | TBFG_11651 (Rv1635c) | conserved transmembrane protein | TBFG_11652 (Rv1636) | iron-regulated hypothetical protein TB15.3 | ← | 11 | 171 | → | |
| 1857726 | G | A | TBFG_11667 (Rv1650) | phenylalanyl-tRNA synthetase beta subunit pheT | TBFG_11668 (Rv1651c) | PE-PGRS family protein | → | 82 | 12 | ← | |
| 2047165 | G | T | TBFG_11829 (Rv1798) | hypothetical protein | TBFG_11830 (Rv1799) | lipoprotein lppT | → | 381 | 246 | → | |
| 2057918 | T | G | TBFG_11837 (Rv1807) | PPE family protein | TBFG_11838 (Rv1808) | PPE family protein | → | 69 | 255 | → | |
| 2117028 | C | T | TBFG_11888 (Rv1860) | alanine and proline rich secreted protein apa | TBFG_11889 (Rv1861) | conserved transmembrane protein | → | 125 | 327 | → | |
| 2150646 | T | C | TBFG_11923 (no ortholog) | hypothetical protein | TBFG_11924 (Rv1895) | hypothetical dehydrogenase | → | 57 | 91 | → | |
| 2268593 | T | G | TBFG_12044 (Rv2012) | hypothetical protein | TBFG_12045 (Rv2013) | transposase | → | 519 | 185 | → | |
| 2465586 | G | A | TBFG_12218 (Rv2190c) | hypothetical protein | TBFG_12219 (Rv2191) | hypothetical protein | ← | 87 | 436 | → | |
| 2572792 | A | C | TBFG_12310 (Rv2288) | hypothetical protein | TBFG_12313 (Rv2290) | lipoprotein lppO | → | 299 | 538 | → | |
| 2573059 | G | C | TBFG_12310 (Rv2288) | hypothetical protein | TBFG_12313 (Rv2290) | lipoprotein lppO | → | 566 | 271 | → | |
| 2586138 | T | G | TBFG_12326 (Rv2303c) | hypothetical antibiotic-resistance protein | TBFG_12327 (Rv2305) | hypothetical protein | ← | 331 | 459 | → | |
| 2592477 | A | C | TBFG_12332 (Rv2308) | hypothetical protein | TBFG_12333 (Rv2309c) | hypothetical integrase | → | 554 | 154 | ← | |
| 2755054 | C | A | TBFG_12469 (Rv2442c) | 50S ribosomal protein L21 rplU | TBFG_12470 (Rv2443) | C4-dicarboxylate-transport transmembrane protein dctA | ← | 19 | 329 | → | |
| 2848894 | A | G | TBFG_12539 (Rv2518c) | lipoprotein lppS | TBFG_12540 (Rv2519) | PE family protein | ← | 241 | 209 | → | |
| 2959155 | A | G | TBFG_12635 (Rv2616) | hypothetical protein | TBFG_12636 (Rv2617c) | hypothetical protein | → | 8 | 9 | ← | |
| 2982625 | A | C | TBFG_12662 (Rv2643) | hypothetical protein | TBFG_12663 (Rv2645) | hypothetical protein | → | 476 | 815 | → | |
| 3023789 | T | C | TBFG_12709 (Rv2694c) | hypothetical protein | TBFG_12710 (Rv2695) | conserved alanine rich protein | ← | 67 | 82 | → | |
| 3144422 | G | A | TBFG_12838 (Rv2824c) | hypothetical protein | TBFG_12839 (Rv2825c) | hypothetical protein | ← | 70 | 108 | ← | |
| 3593078 | C | T | TBFG_13227 (Rv3203) | lipase lipV | TBFG_13228 (Rv3204) | hypothetical DNA-methyltransferase (modification methylase) | → | 2 | 1 | → | |
| 3783234 | T | G | TBFG_13392 (Rv3356c) | bifunctional protein folD: methylenetetrahydrofolate dehydrogenase + methenyltetrahydrofolate cyclohydrolase | TBFG_13393 (Rv3357) | hypothetical protein | ← | 119 | 5 | → | |
| 3807359 | G | A | TBFG_13415 (Rv3379c) | 1-deoxy-D-xylulose 5-phosphate synthase dxs2 | TBFG_13416 (Rv3382c) | lytB-related protein lytB1 | ← | 17 | 206 | ← | |
| 3845950 | G | A | TBFG_13449 (Rv3415c) | hypothetical protein | TBFG_13450 (Rv3416) | transcriptional regulatory protein whib-like whiB3 | ← | 137 | 234 | → | |
| 3863908 | G | A | TBFG_13468 (Rv3431c) | transposase | TBFG_13469 (Rv3432c) | glutamate decarboxylase gadB | ← | 58 | 175 | ← | |
| 3906385 | T | A | TBFG_13511 (Rv3476c) | dicarboxylic acid transport integral membrane protein kgtP | TBFG_13512 (Rv3477) | PE family protein | ← | 312 | 61 | → | |
| 3908044 | C | G | TBFG_13513 (Rv3478) | PPE family protein | TBFG_13514 (Rv3479) | hypothetical protein | → | 84 | 99 | → | |
| 3950434 | A | G | TBFG_13542 (Rv3508) | PE-PGRS family protein | TBFG_13543 (Rv3509c) | acetohydroxyacid synthase ilvX | → | 51 | 116 | ← | |
| 4092855 | A | C | TBFG_13671 (Rv3640c) | transposase | TBFG_13672 (Rv3641c) | cell filamentation protein fic | ← | 103 | 73 | ← | |
| 4093982 | G | A | TBFG_13672 (Rv3641c) | cell filamentation protein fic | TBFG_13673 (Rv3644c) | hypothetical DNA polymerase | ← | 419 | 537 | ← | |
| 4112345 | T | C | TBFG_13690 (Rv3660c) | hypothetical protein | TBFG_13691 (Rv3661) | hypothetical protein | ← | 196 | 303 | → | |
| 4264088 | A | G | TBFG_13830 (Rv3796) | hypothetical protein | TBFG_13831 (Rv3797) | acyl-CoA dehydrogenase fadE35 | → | 82 | 22 | → | |
| 4279669 | T | C | TBFG_13838 (Rv3804c) | secreted antigen 85-A fbpA (fibronectin-binding protein A) | TBFG_13839 (Rv3805c) | conserved transmembrane protein | ← | 10 | 285 | ← | |
| 4364065 | C | A | TBFG_13907 (Rv3872) | PE family protein | TBFG_13908 (Rv3873) | PPE family protein | → | 24 | 10 | → | |
| 4389098 | G | A | TBFG_13928 (Rv3893c) | PE family protein | TBFG_13929 (Rv3894c) | hypothetical protein | ← | 103 | 164 | ← | |
| 533885 | - | T | TBFG_10446 (Rv0441c) | hypothetical protein | TBFG_10447 (Rv0442c) | PPE family protein | ← | 43 | 35 | ← | |
| 1105603 | - | A | TBFG_11003 (Rv0985c) | large-conductance ion mechanosensitive channel mscL | TBFG_11004 (Rv0986) | hypothetical adhesion component transport ATP-binding protein ABC transporter | ← | 364 | 1 | → | |
| 1268756 | - | CCG | TBFG_11159 (Rv1136) | hypothetical enoyl-CoA hydratase | TBFG_11160 (no ortholog) | hypothetical protein | → | 52 | 42 | → | |
| 2452397 | G | - | TBFG_12205 (Rv2177c) | transposase | TBFG_12206 (Rv2178c) | 3-deoxy-D-arabino- heptulosonate 7-phosphate synthase aroG |
← | 257 | 138 | ← | |
| 3867421 | T | - | TBFG_13471 (Rv3434c) | conserved transmembrane protein | TBFG_13472 (Rv3435c) | conserved transmembrane protein | ← | 17 | 230 | ← | |