Cryptococcus neoformans var. grubii H99 Database
Cryptococcus neoformans is an opportunistic fungal pathogen that may cause meningitis in immunocompromised individuals. Often found in soils contaminated with bird feces, C. neoformans enters its host through the lungs via inhalation of spores. In healthy individuals the infection is usually controlled and asymptomatic, but in immunocompromised hosts the fungus can spread via the blood to infect the central nervous system and cause meningitis that is uniformly fatal if untreated. Few antifungal agents exist and drug-resistant strains are emerging. C. neoformans, a member of the Basidiomycota phylum of the fungi, is more closely related to mushrooms than to ascomycete fungi like Saccharomyces cerevisiae or Candida albicans or filamentous fungi such as Neurospora crassa or Aspergillus nidulans.
This release of gene predictions for the serotype A isolate Cryptococcus neoformans var. grubii H99 is based on a new genomic assembly provided by Dr. Fred Dietrich at the Duke Center for Genome Technology. The new assembly consists of 14 nuclear chromosomes and a single 21 KB mitochondrial chromosome, and has resulted in a reduction of the estimated genome size from 19.5 to 18.9 Mb. Improvements in the assembly and in our annotation process have resulted in a set of 6,967 predicted protein products, 335 fewer than the previous release. A file mapping annotations between the current and previous versions may be downloaded here.
ToolsBLAST Search: Find similarities to other sequences Feature Search: Search and view annotated features on the sequence Browse Regions: Retrieve DNA, find clones, and graphically view sequence regions Gene Index: Find genes by a variety of methods Genome Statistics:View basic statistics about genome size, gene density, etc Download Data: Download sequence, genes, markers, and other genome data InformationContact Us:Addresses for contacting the Broad Institute Related Links:Links to sites related to the Cryptococcus neoformans var. grubii H99 genome project |
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