David Root is director of the RNA Interference platform and project leader of The RNAi Consortium (TRC) at the Broad Institute. He oversees the development and production of RNAi libraries, the development of RNAi screening methodologies, and the execution of RNAi-based mammalian genetic screens in collaboration with laboratories in the Broad community.
He worked at the Whitehead Institute in Brent Stockwell's laboratory using high-throughput cell-based compound screening to discover a compound that affects levels of the SMN protein associated with the disease spinal muscular atrophy. David then joined The RNAi Consortium and developed methods for production of a lentiviral RNAi library. Previously, he was assistant professor of chemistry at Swarthmore College.
David received his B.A. in chemistry from Swarthmore College (1990) and Ph.D. in physical chemistry from Stanford University (1997).