The Broad Institute was funded as an U54 Data Generation and Analysis center for LINCS 2011-2014 and charged with creating a first installment of a large-scale transcriptional dataset.
LINCS resources created during this grant period are freely available for all users. These resources include:
In the next phase of LINCS, we plan to develop perturbational profiles for LINCS using L1000, explore sequencing-based approaches for transcriptional profiling of a wider set of genes and profiling novel genetic reagents including improved gain-of-function (cDNA) and loss-of-function (CRISPR) genetic libraries
As the NIH and our aims take shape, we will post more information. In the interim, if you have any questions, please contact us at firstname.lastname@example.org.
A database of ~7,000 Affymetrix gene expression profiles representing ~1,300 compounds. This resource continues to be made available in maintenance-mode.
We have developed a modern, cloud-based informatics platform that is engineered to support the dramatically large datasets that the L1000 assay has enabled. Academic users would probably find access via http://lincscloud.org more useful as it includes bench biologist friendly user interfaces, visualization methods and collaboration tools. (it is a superset of the resources on this website).
Our mission in Connectivity Map is to develop comprehensive signatures of cellular states and the tools to analyze them. Despite generous NIH and philanthropic contributions over the past 10 years, there still remains much to be done to execute on the original vision. We are developing ideas to support this effort. Stay tuned for more information.